A case-control study on colorectal cancer was conducted in Hangzhou,China. The study involved 245 cases diagnosed as colorectal adenocarcinoma and the same number of populationbased controls matched by sex,age group and resident sites. The results showed that risks for colorectal cancer were significantly associated with alcohol drinking (OR 1.7 3, 9 5% CI 1.0 7~2.79), the history of chronic diarrhea (OR 5.5 5, 9 5% CI 1.4 9~2 0.7 3), bloody stools (OR 6.21, 95% CI 2.82~13.67),tap-water drinking (OR 1.03, 95% CI 1.01~1.05),and heavy physical labor (OR 1.02, 95% CI 1.00~1.04). While the only negative case associated with colorectal cancer was found to have light physical activities, (OR 0.9, 95% CI 0.80~0.98).The authors maintained that this study might provide some epidemiological basis for preventive strategies of colorectal cancer in China particularly in Hangzhou area.