Experiments were performend on vagotomized as well as on vagus intact anaesthetized rab-bits, observation and comparison were made on ST-segment deflection, ventricular premature con-traction(VPC) and pressor response induced simple or simultaneous stimulation of dorsomedial hypothalamic nucleus (DMH) and paraventricular hypothalamic nucleus (PVH). The results suggest that DMH is one of the areas with high response in eliciting ischemic ECG-ST segment change, and PVH is one of the key areas involved in the production of VPC and pressor re-sponse. When PVH and DMH were stimulated simultaneously, the two above mentioned re-sponses were augmented cooperatively. As prominent myocardial ischemic arrhythmia can be provoked in vagotomized rabbits, comparison between the results in vagus intact rabbits and those in vagotomized rabbits indicates that the presence of vagus nerve can reduce ST-segment deflec-tion induced by DMH and PVH+DMH stimulation, suggesting vagus might possess a protective action on neurogenic myocardial ischemia, but no significant influence on VPC and pressor re-sponse induced by stimulation of hypothalamus.