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浙江大学学报(医学版)  1993, Vol. 22 Issue (2): 57-60    DOI: 10.3785/j.issn.1008-9292.1993.02.005
基础医学     
实验性免疫反应性中耳炎对内耳的影响
徐娅苹, 王辉萼, 蔡钺侯
附属第二医院耳鼻咽喉科
EFFECTS OF EXPERIMENTAL MIDDLE EAR IMMUNE RESPONSE ON INNER EAR
Xu Yaping, Wang Huie, Cai Yuehou
Ear-nose-throat Department of the Second Affiliated Hospital
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摘要:

作者应用免疫荧光技术,对实验性免疫反应性中耳炎模型进行了研究。结果显示:实验动物早期出现前庭功能紊乱;免疫荧光分布于中耳粘膜和前庭囊壁上皮下、耳蜗血管纹和基底膜近蜗轴处;免疫荧光强度测定蜗底多、蜗顶少。

关键词: 中耳炎免疫反应抗原迷路/免疫学    
Abstract:

By applying the technique of immune-fluorescence. we have made an animal model of oti tis media with effusion induced by immune response in guinea pigs. The findings are as fol-lows:The guinea pigs showed early imbalance and spontaneous nystagmus, indicating that the antigen from middle ear could spread into the inner ear and result in immune-complex in-duced reaction to disturb the labyrinth function. The immune-fluorescence distributed in the subepithelial layer of the middle ear and vestibular, scattered in stria vascularis and the basi-lar membrane around the modiolus of cochlear. It is speculated that the immune response af-fects the oxygenic supply of Cortic organ and energy metablism in the inner ear. The intensity of fluorescence in the apex turn of cochlear was lower than that in the base turn. So it is probable that otitis media with effusion of immune response might damage the base turn car ly.

Key words: Otitis    Labyrinth/immunol    Antigens immune respons
收稿日期: 1992-05-01 出版日期: 1993-03-25
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引用本文:

徐娅苹, 王辉萼, 蔡钺侯. 实验性免疫反应性中耳炎对内耳的影响[J]. 浙江大学学报(医学版), 1993, 22(2): 57-60.

Xu Yaping, Wang Huie, Cai Yuehou. EFFECTS OF EXPERIMENTAL MIDDLE EAR IMMUNE RESPONSE ON INNER EAR. Journal of ZheJiang University(Medical Science), 1993, 22(2): 57-60.

链接本文:

https://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.1993.02.005        https://www.zjujournals.com/med/CN/Y1993/V22/I2/57

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