不同剂量的维生素K3(5、10和20μg/ml)对体外人直肠癌细胞系(HR-8348)及早幼粒细胞白血病细胞株(HL-60)均显示明显抑制作用,且有剂量依赖性。随着维生素K3与HL-60细胞接触时间的延长,抑制作用亦增强,维生素K320μg/ml与细胞接触48h作用已近高峰。当5-氟尿嘧啶10μg/ml和维生素K35μg/ml同时加入体外培养的HR-8348细胞后48h,未显示相加作用。
The growth of HR-8348 and HL-60 cells was inhibited significantly in vitro by Vitamine K3 of various concentrations(5,10 and 20μg/ml). Yet it was dose-dependent. The inhibitory effect on cell growth became stronger with longer contact of Vitamine K3 with HL-60 cells. The most potent inhibitory effect showed up 48 hours after the contact of cancer cells with 20μg/ml of vitamine K3. Co-administration of 5-FU 10μg/ml and Vitamine K3 5μg/ml to the HR-8348 cells in vitro for 48 hours did't exhibit any additive effect.
耿宝琴, 俞伟红. 维生素K3对人癌细胞的抑制作用[J]. 浙江大学学报（医学版）, 1990, 19(3): 110-112.
Geng Baochin, Yu Weihong. INHIBITORY EFFECT OF VITAMINE K3 ON HUMAN CANCER CELLS. Journal of ZheJiang University(Medical Science), 1990, 19(3): 110-112.
https://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.1990.03.006 或 https://www.zjujournals.com/med/CN/Y1990/V19/I3/110
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