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浙江大学学报（医学版）
浙江大学学报（医学版）  2022, Vol. 51 Issue (5): 634-639    DOI: 10.3724/zdxbyxb-2022-0224
细胞因子     
血小板衍生生长因子及其受体在脑出血中的作用
毛宝杰1,2,王明2,*(),万曙2,*()
1. 浙江中医药大学第二临床医学院，浙江 杭州 310053
2. 浙江大学医学院附属浙江医院脑科中心，浙江 杭州 310030
Platelet derived growth factor and its receptor in intracerebral hemorrhage
MAO Baojie1,2,WANG Ming2,*(),WAN Shu2,*()
1. The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China;
2. Brain Center, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou 310030, China
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摘要：

脑出血是成人常见致死致残性神经系统疾病。血小板衍生生长因子（PDGF）信号通路对脑出血的发生发展起着重要作用。PDGF参与血管重塑，可以作为脑出血的主要病因之一脑淀粉样血管病的生物标志物；PDGF及其受体通过改变血脑屏障完整性及促进炎症反应参与脑出血后继发性损伤机制，还可能通过促进血管生成参与脑出血后的修复机制。本文综述了PDGF信号通路参与脑出血病理生理的最新研究进展，介绍了以PDGF受体为治疗靶点的相关拮抗剂，旨在为脑出血临床治疗方案提供依据。
关键词： 脑出血;  血小板衍生生长因子;  血小板衍生生长因子受体;  炎症;  血脑屏障;  综述    
Abstract:

Intracerebral hemorrhage (ICH) is a common and highly disabling or fatal neurological disorder in adults. Recent studies have suggested that the platelet derived growth factor (PDGF) signaling pathway plays an important role in the development of ICH. PDGF is involved in vascular remodeling and can be used as a biomarker of cerebral amyloid angiopathy which is one of the major causes of ICH. PDGF and its receptors are involved in the mechanism of the secondary injury after ICH by affecting the integrity of the blood-brain barrier and inflammatory response. PDGF and its receptors may also participate in the mechanism of repair after ICH by promoting angiogenesis. This article reviews the latest research progress on the involvement of PDGF signaling pathway in the pathophysiology of intracerebral hemorrhage, and introduces the relevant antagonists using PDGFR as the therapeutic target, to provide information for the development of therapeutic options for intracerebral hemorrhage.
Key words: Intracerebral hemorrhage    Platelet derived growth factor    Platelet derived growth factor receptor    Inflammation    Blood-brain barrier    Review
收稿日期: 2022-05-04 出版日期: 2022-12-28
CLC:  R43.34  
基金资助: 浙江省自然科学基金（Y21H090041）；浙江省重点研发项目（2021C03105）；浙江省医药卫生科技计划（WKJ-ZJ-2014）
通讯作者: 王明,万曙     E-mail: u
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引用本文:

毛宝杰,王明,万曙. 血小板衍生生长因子及其受体在脑出血中的作用[J]. 浙江大学学报（医学版）, 2022, 51(5): 634-639.

MAO Baojie,WANG Ming,WAN Shu. Platelet derived growth factor and its receptor in intracerebral hemorrhage. J Zhejiang Univ (Med Sci), 2022, 51(5): 634-639.

链接本文:

https://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2022-0224    或    https://www.zjujournals.com/med/CN/Y2022/V51/I5/634

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