| meta分析 |
|
|
|
|
| 抗抑郁药物治疗儿童青少年抑郁症疗效和耐受性的网状meta分析 |
饶燕晓1,杨荣旺1,*( ),赵京2,曹庆久3 |
1. 浙江大学医学院附属儿童医院心理科 国家儿童健康与疾病临床医疗研究中心 国家儿童区域医疗中心， 浙江 杭州 310052
2. 中国人民解放军联勤保障部队第九八四医院脑四科，北京 100094
3. 北京大学精神卫生研究所，北京 100083 |
|
| Efficacy and tolerability of antidepressant drugs in treatment of depression in children and adolescents: a network meta-analysis |
| RAO Yanxiao1,YANG Rongwang1,*(),ZHAO Jing2,CAO Qingjiu3 |
1. Department of Psychology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Medical Center for Children, Hangzhou 310052, China;
2. The Fourth Department of Brain Medicine, the 984th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Beijing 100094, China;
3. Institute of Mental Health, Peking University, Beijing 100083, China |
引用本文:
饶燕晓,杨荣旺,赵京,曹庆久. 抗抑郁药物治疗儿童青少年抑郁症疗效和耐受性的网状meta分析[J]. 浙江大学学报（医学版）, 2022, 51(4): 480-490.
RAO Yanxiao,YANG Rongwang,ZHAO Jing,CAO Qingjiu. Efficacy and tolerability of antidepressant drugs in treatment of depression in children and adolescents: a network meta-analysis. J Zhejiang Univ (Med Sci), 2022, 51(4): 480-490.
链接本文:
https://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2022-0145
或
https://www.zjujournals.com/med/CN/Y2022/V51/I4/480
|
| 1 |
FERRARI A J , SOMERVILLE A J , BAXTER A J , et al.Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature[J]Psychol Med, 2013, 43( 3): 471-481.
doi: 10.1017/S0033291712001511
|
| 2 |
VOS T , LIM S S , ABBAFATI C , et al.Global burden of 369 diseases and injuries in 204 countries and territories, 1990—2019: a systematic analysis for the Global Burden of Disease Study 2019[J]Lancet, 2020, 396( 10258): 1204-1222.
doi: 10.1016/S0140-6736(20)30925-9
|
| 3 |
MOJTABAI R , OLFSON M , HAN B . National trends in the prevalence and treatment of depression in adolescents and young adults[J/OL]Pediatrics, 2016, 138( 6): e20161878.
doi: 10.1542/peds.2016-1878
|
| 4 |
MATHERS C D , LONCAR D . Projections of global mortality and burden of disease from 2002 to 2030[J/OL]PLoS Med, 2006, 3( 11): e442.
doi: 10.1371/journal.pmed.0030442
|
| 5 |
ALAIE I , SSEGONJA R , PHILIPSON A , et al.Adolescent depression, early psychiatric comorbidities, and adulthood welfare burden: a 25-year longitudinal cohort study[J]Soc Psychiatry Psychiatr Epidemiol, 2021, 56( 11): 1993-2004.
doi: 10.1007/s00127-021-02056-2
|
| 6 |
HAZELL P . Updates in treatment of depression in children and adolescents[J]Curr Opin Psychiatry, 2021, 34( 6): 593-599.
doi: 10.1097/YCO.0000000000000749
|
| 7 |
COUSINS L , GOODYER I M . Antidepressants and the adolescent brain[J]J Psychopharmacol, 2015, 29( 5): 545-555.
doi: 10.1177/0269881115573542
|
| 8 |
MERUELO A D , BRUMBACK T , NAGEL B J , et al.Neuroimaging markers of adolescent depression in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study[J]J Affective Disord, 2021, 380-386.
doi: 10.1016/j.jad.2021.03.071
|
| 9 |
高贵元, 黄 捷, 刘 丹, 等. 抑郁症的发病机制及抗抑郁药物的研究进展[J]. 中国医药导报, 2021, 18(1): 52-55, 70
GAO Guiyuan, HUANG Jie, LIU Dan, et al. The pathogenesis of depression and the research progress of antidepressants[J]. China Medical Herald, 2021, 18(1): 52-55, 70. (in Chinese)
|
| 10 |
FINDLING R L , PAGANO M E , MCNAMARA N K , et al.The short-term safety and efficacy of fluoxetine in depressed adolescents with alcohol and cannabis use disorders: a pilot randomized placebo-controlled trial[J]Child Adolesc Psychiatry Ment Health, 2009, 3( 1): 11.
doi: 10.1186/1753-2000-3-11
|
| 11 |
MARCH J , SILVA S , PETRYCKI S , et al.Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression[J]JAMA, 2004, 292( 7): 807-820.
doi: 10.1001/jama.292.7.807
|
| 12 |
ATKINSON S D , PRAKASH A , ZHANG Q , et al.A double-blind efficacy and safety study of duloxetine flexible dosing in children and adolescents with major depressive disorder[J]J Child Adolesc Psychopharmacol, 2014, 24( 4): 180-189.
doi: 10.1089/cap.2013.0146
|
| 13 |
ATTARI A, YADOLLAH M F, HASAN Z A, et al. Comparison of efficacy of fluoxetine with nortriptyline in treatment of major depression in children and adolescents: a double-blind study[J]. J Res Med Sci, 2006, 11: 24-30
|
| 14 |
DELBELLO M P , HOCHADEL T J , PORTLAND K B , et al.A double-blind, placebo-controlled study of selegiline transdermal system in depressed adolescents[J]J Child Adolesc Psychopharmacol, 2014, 24( 6): 311-317.
doi: 10.1089/cap.2013.0138
|
| 15 |
KYE C H , WATERMAN G S , RYAN N D , et al.A randomized, controlled trial of amitriptyline in the acute treatment of adolescent major depression[J]J Am Acad Child Adolesc Psychiatry, 1996, 35( 9): 1139-1144.
doi: 10.1097/00004583-199609000-00011
|
| 16 |
WEIHS K L , MURPHY W , ABBAS R , et al.Desvenlafaxine versus placebo in a fluoxetine- referenced study of children and adolescents with major depressive disorder[J]J Child Adolesc Psychopharmacol, 2018, 28( 1): 36-46.
doi: 10.1089/cap.2017.0100
|
| 17 |
杜海霞, 郭 芳, 郭素芹, 等. 文拉法辛与氟西汀治疗儿童抑郁症对照研究[J]. 临床心身疾病杂志, 2008, 14(1): 7-9
DU Haixia, GUO Fang, GUO Suqin, et al. A control study of venlafaxine vs fluoxetine in the treatment of child depression[J]. Journal of Clinical Psychosomatic Diseases, 2008, 14(1): 7-9. (in Chinese)
|
| 18 |
BRESLAU N, DAVIS G C. Refining DSM-Ⅲ criteria in major depression. An assessment of the descriptive validity of criterion symptoms[J]. J Affect Disord, 1985, 9(3): 199-206
|
| 19 |
KESSLER R C, WALTERS E E. Epidemiology of DSM-Ⅲ-R major depression and minor depression among adolescents and young adults in the National Comorbidity Survey[J]. Depress Anxiety, 1998, 7(1): 3-14
|
| 20 |
SIMON G E, VON KORFF M. Medical co-morbidity and validity of DSM-Ⅳ depression criteria[J]. Psychol Med, 2006, 36(1): 27-36
|
| 21 |
MASKE U E, BUTTERY A K, BEESDO-BAUM K, et al. Prevalence and correlates of DSM-Ⅳ-TR major depressive disorder, self-reported diagnosed depression and current depressive symptoms among adults in Germany[J]. J Affect Disord, 2016, 190: 167-177
|
| 22 |
PEDERSEN S H, STAGE K B, BERTELSEN A, et al. ICD-10 criteria for depression in general practice[J]. J Affect Disord, 2001, 65(2): 191-194
|
| 23 |
中华医学会精神科分会. 中国精神疾病分类方案与诊断标准[M]. 3版. 济南: 山东科学技术出版社, 2001: 87-88
Chinese Society of Psychiatry of Chinese Medical Association. Chinese classification of mental disorders (CCMD-3)[M]. 3rd ed. Jinan: Shandong Science and Technology Press, 2001: 87-88. (in Chinese)
|
| 24 |
RIEDEL M , MÖLLER H J , OBERMEIER M , et al.Response and remission criteria in major depression — a validation of current practice[J]J Psychiatric Res, 2010, 44( 15): 1063-1068.
doi: 10.1016/j.jpsychires.2010.03.006
|
| 25 |
张 渊, 杨智荣, 孙 凤, 等. 偏倚风险评估系列: (九) 如何应用偏倚风险评估的结果[J]. 中华流行病学杂志, 2018, 39(12): 1648-1654
ZHANG Yuan, YANG Zhirong, SUN Feng, et al. Risk of bias assessment: (9) application of the risk of bias assessment results[J]. Chinese Journal of Epidemiology, 2018, 39(12): 1648-1654. (in Chinese)
|
| 26 |
张 超, 鄢金柱, 孙 凤, 等. 网状meta分析一致性的鉴别与处理方法[J]. 中国循证医学杂志, 2014, 14(7): 884-888
ZHANG Chao, YAN Jinzhu, SUN Feng, et al. Differentiation and handling of homogeneity in network meta- analysis[J]. Chinese Journal of Evidence-Based Medicine, 2014, 14(7): 884-888. (in Chinese)
|
| 27 |
SHIM S , YOON B H , SHIN I S , et al.Network meta-analysis: application and practice using Stata[J/OL]Epidemiol Health, 2017, e2017047.
doi: 10.4178/epih.e2017047
|
| 28 |
WAGNER K D , JONAS J , FINDLING R L , et al.A double-blind, randomized, placebo-controlled trial of escitalopram in the treatment of pediatric depression[J]J Am Acad Child Adolesc Psychiatry, 2006, 45( 3): 280-288.
doi: 10.1097/01.chi.0000192250.38400.9e
|
| 29 |
PUIG-ANTICH J , PEREL J M , LUPATKIN W , et al.Imipramine in prepubertal major depressive disorders[J]Arch Gen Psychiatry, 1987, 44( 1): 81-89.
doi: 10.1001/archpsyc.1987.01800130093012
|
| 30 |
GELLER B , COOPER T B , GRAHAM D L , et al.Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6 to 12-year-olds with major depressive disorder[J]J Am Acad Child Adolesc Psychiatry, 1992, 31( 1): 34-44.
doi: 10.1097/00004583-199201000-00007
|
| 31 |
FINDLING R L , ROBB A , BOSE A . Escitalopram in the treatment of adolescent depression: a randomized, double-blind, placebo-controlled extension trial[J]J Child Adolesc PsychoPharmacol, 2013, 23( 7): 468-480.
doi: 10.1089/cap.2012.0023
|
| 32 |
EMSLIE G J , RUSH A J , WEINBERG W A , et al.A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression[J]Arch Gen Psychiatry, 1997, 54( 11): 1031-1037.
doi: 10.1001/archpsyc.1997.01830230069010
|
| 33 |
WAGNER K D , AMBROSINI P , RYNN M , et al.Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder two randomized controlled trials[J]JAMA, 2003, 290( 8): 1033-1041.
doi: 10.1001/jama.290.8.1033
|
| 34 |
RYNN M , WAGNER K D , DONNELLY C , et al.Long-term sertraline treatment of children and adolescents with major depressive disorder[J]J Child Adolesc Psychopharmacol, 2006, 16( 1-2): 103-116.
doi: 10.1089/cap.2006.16.103
|
| 35 |
LE NOURY J , NARDO J M , HEALY D , et al.Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence[J]BMJ, 2015, h4320.
doi: 10.1136/bmj.h4320
|
| 36 |
KELLER M B , RYAN N D , STROBER M , et al.Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial[J]J Am Acad Child Adolesc Psychiatry, 2001, 40( 7): 762-772.
doi: 10.1097/00004583-200107000-00010
|
| 37 |
EMSLIE G J , PRAKASH A , ZHANG Q , et al.A double-blind efficacy and safety study of duloxetine fixed doses in children and adolescents with major depressive disorder[J]J Child Adolesc Psychopharmacol, 2014, 24( 4): 170-179.
doi: 10.1089/cap.2013.0096
|
| 38 |
BERARD R , FONG R , CARPENTER D J , et al.An international, multicenter, placebo-controlled trial of paroxetine in adolescents with major depressive disorder[J]J Child Adolesc Psychopharmacol, 2006, 16( 1-2): 59-75.
doi: 10.1089/cap.2006.16.59
|
| 39 |
DURGAM S , CHEN C , MIGLIORE R , et al.A phase 3, double-blind, randomized, placebo-controlled study of vilazodone in adolescents with major depressive disorder[J]Pediatr Drugs, 2018, 20( 4): 353-363.
doi: 10.1007/s40272-018-0290-4
|
| 40 |
EMSLIE G J , HEILIGENSTEIN J H , WAGNER K D , et al.Fluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trial[J]J Am Acad Child Adolesc Psychiatry, 2002, 41( 10): 1205-1215.
doi: 10.1097/00004583-200210000-00010
|
| 41 |
EMSLIE G J , VENTURA D , KOROTZER A , et al.Escitalopram in the treatment of adolescent depression: a randomized placebo-controlled multisite trial[J]J Am Acad Child Adolesc Psychiatry, 2009, 48( 7): 721-729.
doi: 10.1097/CHI.0b013e3181a2b304
|
| 42 |
WAGNER K D , ROBB A S , FINDLING R L , et al.A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescents[J]Am J Psychiatry, 2004, 161( 6): 1079-1083.
doi: 10.1176/appi.ajp.161.6.1079
|
| 43 |
张锦绣. 艾司西酞普兰与舍曲林治疗青少年抑郁障碍的对照研究[J]. 中国民族民间医药, 2012, 21(16): 27-28
ZHANG Jinxiu. A control study of escitalopram vs sertraline in the treatment of juvenile depression[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2012, 21(16): 27-28. (in Chinese)
|
| 44 |
季卫东, 郭田友, 杨 闯, 等. 盐酸文拉法辛缓释胶囊治疗青少年抑郁症对照研究[J]. 中国临床药理学与治疗学, 2008, 13(1): 117-120
JI Weidong, GUO Tianyou, YANG Chuang, et al. A randomized and double-blind clinical trail of venlafaxine hydrochloride sustained release capsules for treating juvenile depression[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(1): 117-120. (in Chinese)
|
| 45 |
EMSLIE G J , FINDLING R L , YEUNG P P , et al.Venlafaxine ER for the treatment of pediatric subjects with depression[J]J Am Acad Child Adolesc Psychiatry, 2007, 46( 4): 479-488.
doi: 10.1097/chi.0b013e31802f5f03
|
| 46 |
EMSLIE G J , WAGNER K D , KUTCHER S , et al.Paroxetine treatment in children and adolescents with major depressive disorder: a randomized, multicenter, double-blind, placebo-controlled trial[J]J Am Acad Child Adolesc Psychiatry, 2006, 45( 6): 709-719.
doi: 10.1097/01.chi.0000214189.73240.63
|
| 47 |
FINDLING R L , MCCUSKER E , STRAWN J R . A randomized, double-blind, placebo-controlled trial of vilazodone in children and adolescents with major depressive disorder with twenty-six-week open-label follow- up[J]J Child Adolesc Psychopharmacol, 2020, 30( 6): 355-365.
doi: 10.1089/cap.2019.0176
|
| 48 |
万 纯, 兰胜作, 王宇峰, 等. 西酞普兰与阿米替林治疗首发少年抑郁症的对照研究[J]. 中国行为医学科学, 2006, 15(12): 1137-1138
WAN Chun, LAN Shengzuo, WANG Yufeng, et al. A control study of citalopram vs amitriptyline in the treatment of juvenile depression[J]. Chinese Journal of Behavioral Medicine and Brain Science, 2006, 15(12): 1137-1138. (in Chinese)
|
| 49 |
闫凤娟, 刘雪峰. 艾司西酞普兰与氟西汀治疗儿童抑郁症对照研究[J]. 中国中西医结合儿科学, 2014, 6(2): 139-140
YAN Fengjuan, LIU Xuefeng. A control study of escitalopram vs fluoxetine in the treatment of children depression[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2014, 6(2): 139-140. (in Chinese)
|
| 50 |
KLEIN R G , MANNUZZA S , KOPLEWICZ H S , et al.Adolescent depression: controlled desipramine treatment and atypical features[J]Depress Anxiety, 1998, 7( 1): 15-31.
doi: 10.1002/(SICI)1520-6394(1998)7:1<15::AID-DA3>3.0.CO;2-4
|
| 51 |
ATKINSON S , LUBACZEWSKI S , RAMAKER S , et al.Desvenlafaxine versus placebo in the treatment of children and adolescents with major depressive disorder[J]J Child Adolesc Psychopharmacol, 2018, 28( 1): 55-65.
doi: 10.1089/cap.2017.0099
|
| 52 |
IZAKI Y. Depression among adolescents: clinical features and interventions[J]. J Med Invest, 2021, 68(1.2): 22-28
|
| 53 |
STAHL S M. Stahl’s essential psychopharmacology: neuroscientific basis and practical applications[M]. 4th ed. Cambridge: Cambridge University Press, 2013: 433-468
|
| 54 |
ZHOU X , TENG T , ZHANG Y , et al.Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta- analysis[J]Lancet Psychiatry, 2020, 7( 7): 581-601.
doi: 10.1016/S2215-0366(20)30137-1
|
| 55 |
BOADEN K , TOMLINSON A , CORTESE S , et al.Antidepressants in children and adolescents: meta-review of efficacy, tolerability and suicidality in acute treatment[J]Front Psychiatry, 2020, 717.
doi: 10.3389/fpsyt.2020.00717
|
| 56 |
李 玥, 贺 敏, 张磊阳, 等. 抗抑郁药物的研究进展[J]. 临床药物治疗杂志, 2017, 15(1): 8-13
LI Yue, HE Min, ZHANG Leiyang, et al. Progress on antidepressants[J]. Clinical Medication Journal, 2017, 15(1): 8-13. (in Chinese)
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
