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浙江大学学报(医学版)  2022, Vol. 51 Issue (4): 500-506    DOI: 10.3724/zdxbyxb-2022-0077
综述     
间充质干细胞来源的外泌体调节缺血性脑卒中后炎症反应的研究进展
周璐佳1,梁景岩1,2,熊天庆1,2,*
1. 扬州大学医学院 扬州大学转化医学研究院,江苏 扬州 225001
2. 江苏省中西医结合老年病防治重点实验室,江苏 扬州 225001
Research progress of mesenchymal stem cell-derived exosomes on inflammatory response after ischemic stroke
ZHOU Lujia1,LIANG Jingyan1,2,XIONG Tianqing1,2,*
1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China;
2. Jiangsu Provincial Key Laboratory of Geriatric Disease Prevention and Control, Yangzhou 225001, Jiangsu Province, China
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摘要:

缺血性脑卒中发病急、致死率高,而抑制神经炎症是治疗缺血性脑卒中的关键。间充质干细胞(MSC)来源的外泌体因其来源广、直径小、有效成分多而被广泛关注。近期研究表明,MSC来源的外泌体可抑制小胶质细胞、星形胶质细胞的促炎反应活性,刺激其神经保护活性;也可通过调节免疫细胞和炎症介质抑制神经炎症。本文阐述了MSC来源的外泌体在缺血性脑卒中后神经炎症中的作用及其潜在机制,希望为其在缺血性脑卒中疾病的治疗提供思路和借鉴。

关键词: 间充质干细胞外泌体缺血性脑卒中神经胶质细胞炎症介质综述    
Abstract:

Ischemic stroke is characterized by cute onset and high mortality. The suppression of neuroinflammation is crucial in the treatment of ischemic stroke. Exosomes derived from mesenchymal stem cell (MSC) have attracted extensive research attention due to their wide origin, small size, and containing large number of active components. Recent studies have shown that MSC-derived exosomes can inhibit the proinflammatory activity of microglia and astrocytes and stimulate their neuroprotective activity; also can inhibit neuroinflammation by regulating immune cells and inflammatory mediators. This article reviews the roles and related mechanism of MSC-derived exosomes in neuroinflammation after ischemic stroke, hoping to provide ideas and references for the development of a novel approach for the treatment of ischemic stroke diseases.

Key words: Mesenchymal stem cell    Exosome    Ischemic stroke    Neuroglial cell    Inflammatory mediator    Review
收稿日期: 2022-03-01 出版日期: 2022-11-16
CLC:  R743.3  
基金资助: 国家重点研发计划(2016YFE0126000);江苏省“六大人才高峰”高层次人才项目(2018WSN-082);扬州市“绿扬金凤计划”(137012415/5022);扬州大学创新训练项目(X20220737)
通讯作者: 熊天庆   
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引用本文:

周璐佳,梁景岩,熊天庆. 间充质干细胞来源的外泌体调节缺血性脑卒中后炎症反应的研究进展[J]. 浙江大学学报(医学版), 2022, 51(4): 500-506.

ZHOU Lujia,LIANG Jingyan,XIONG Tianqing. Research progress of mesenchymal stem cell-derived exosomes on inflammatory response after ischemic stroke. J Zhejiang Univ (Med Sci), 2022, 51(4): 500-506.

链接本文:

https://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2022-0077        https://www.zjujournals.com/med/CN/Y2022/V51/I4/500

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