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浙江大学学报（医学版）
浙江大学学报（医学版）  2022, Vol. 51 Issue (3): 373-379    DOI: 10.3724/zdxbyxb-2022-0052
综述     
人类免疫缺陷病毒感染早期启动抗逆转录病毒治疗的意义
邵玥明1,荀静娜1,陈军1,*(),卢洪洲2,*()
复旦大学附属公共卫生临床中心 上海市公共卫生临床中心感染与免疫科，上海 201508
南方科技大学附属第二医院 深圳市第三人民医院 国家感染性疾病临床医学研究中心感染一科，广东 深圳 518112
Significance of initiating antiretroviral therapy in the early stage of HIV infection
SHAO Yueming1,XUN Jingna1,CHEN Jun1,*(),LU Hongzhou2,*()
Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China;
Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the Third People’s Hospital of Shenzhen, the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China
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摘要：

人类免疫缺陷病毒（HIV）感染者如在感染早期未及时诊断和治疗，HIV将在体内持续复制，损害免疫系统。目前，越来越多的指南建议HIV感染者应尽早启动抗逆转录病毒治疗（ART），尤其是急性HIV感染者。早发现并在感染早期开始ART可以限制病毒储存库的规模，改善免疫细胞功能。从社会层面而言，感染早期的患者通过启动ART达到病毒抑制状态，可以减少HIV的传播机会，降低获得性免疫缺陷综合征（AIDS）的发病率，进而减少与AIDS相关的卫生支出。但HIV感染早期诊断及治疗存在个人因素和社会因素等方面的问题，阻碍了早期治疗的实施和开展。尽早启动ART，联合其他治疗策略，有可能真正实现功能性治愈。
关键词： 人类免疫缺陷病毒;  获得性免疫缺陷综合征;  抗逆转录病毒治疗;  感染早期;  功能性治愈;  综述    
Abstract:

A growing number of guidelines now recommend that human immunodeficiency virus (HIV) infected patients should be given early antiretroviral therapy (ART), especially in acute HIV infection. ART during early infection can limit viral reservoirs and improve immune cell function. From a societal prospect, early-infected individuals who achieve a state of viral suppression through ART can reduce the chance of HIV transmission and reduce the acquired immunodeficiency syndrome (AIDS)-related disease burden. However, there are many problems in the early diagnosis and treatment of HIV infection, including personal and social factors, which hinder the implementation and development of early treatment. It is recommended that initiating ART in the early stage of HIV infection, combined with other treatment strategies, so as to achieve functional cure.
Key words: Human immunodeficiency virus    Acquired immunodeficiency syndrome    Antiretroviral therapy    Early infection    Functional cure    Review
收稿日期: 2022-02-21 出版日期: 2022-09-21
CLC:  R512.91  
基金资助: 上海市“科技创新行动计划”医学创新研究专项（20MC1920100）；上海市公共卫生体系建设三年行动计划（2020—2022年）重点学科建设（GWV-10.1-XK02）
通讯作者: 陈军,卢洪洲     E-mail: luhongzhou@fudan.edu.cn
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引用本文:

邵玥明,荀静娜,陈军,卢洪洲. 人类免疫缺陷病毒感染早期启动抗逆转录病毒治疗的意义[J]. 浙江大学学报（医学版）, 2022, 51(3): 373-379.

SHAO Yueming,XUN Jingna,CHEN Jun,LU Hongzhou. Significance of initiating antiretroviral therapy in the early stage of HIV infection. J Zhejiang Univ (Med Sci), 2022, 51(3): 373-379.

链接本文:

https://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2022-0052    或    https://www.zjujournals.com/med/CN/Y2022/V51/I3/373

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