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浙江大学学报（医学版）
浙江大学学报（医学版）  2022, Vol. 51 Issue (1): 102-107    DOI: 10.3724/zdxbyxb-2021-0398
综述     
磁性纳米粒子复合支架及外加磁场影响成骨作用的研究进展
汪文妮,陈超群,顾新华
浙江大学医学院附属第一医院口腔科，浙江 杭州 310003
Research progress on effect of magnetic nanoparticle composite scaffold on osteogenesis
WANG Wenni,CHEN Chaoqun,GU Xinhua
Department of Stomatology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
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摘要：

磁性纳米粒子（MNP）具有独特的磁响应性、生物相容性，在作为生物材料时可通过其内在的微小磁场促进成骨分化。掺入MNP的磁性复合支架保留了MNP的超顺磁性，具有良好的物理机械性能以及生物学性能，在体内外均取得良好的成骨效果。外加磁场可通过影响细胞代谢行为促进骨组织修复，与MNP复合支架结合可起到协同促进骨组织修复再生的作用，在骨组织工程领域的应用潜力巨大。本文就MNP复合支架的性能、MNP复合支架和磁场的成骨作用研究进展作一综述，为MNP复合支架进一步研究和临床应用提供参考。
关键词： 磁性纳米粒子;  复合支架;  磁场;  成骨;  综述    
Abstract:

Magnetic nanoparticles (MNP) have been widely used as biomaterials due to their unique magnetic responsiveness and biocompatibility, which also can promote osteogenic differentiation through their inherent micro-magnetic field. The MNP composite scaffold retains its superparamagnetism, which has good physical, mechanical and biological properties with significant osteogenic effects in vitro and in vivo. Magnetic field has been proved to promote bone tissue repair by affecting cell metabolic behavior. MNP composite scaffolds under magnetic field can synergically promote bone tissue repair and regeneration, which has great application potential in the field of bone tissue engineering. This article summarizes the performance of magnetic composite scaffold, the research progress on the effect of MNP composite scaffold with magnetic fields on osteogenesis, to provide reference for further research and clinical application.
Key words: Magnetic nanoparticle    Composite scaffold    Magnetic field    Osteogenesis    Review
收稿日期: 2021-07-15 出版日期: 2022-05-17
CLC:  R459.9  
基金资助: 浙江省自然科学基金（LY20H140002）
通讯作者: 顾新华   
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引用本文:

汪文妮,陈超群,顾新华. 磁性纳米粒子复合支架及外加磁场影响成骨作用的研究进展[J]. 浙江大学学报（医学版）, 2022, 51(1): 102-107.

WANG Wenni,CHEN Chaoqun,GU Xinhua. Research progress on effect of magnetic nanoparticle composite scaffold on osteogenesis. J Zhejiang Univ (Med Sci), 2022, 51(1): 102-107.

链接本文:

https://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2021-0398    或    https://www.zjujournals.com/med/CN/Y2022/V51/I1/102

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