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浙江大学学报（医学版）
浙江大学学报（医学版）  2021, Vol. 50 Issue (5): 545-552    DOI: 10.3724/zdxbyxb-2021-0321
医学与社会     
1990—2019年全球牙周病流行病学负担及社会经济差异所致负担不公平程度分析
韦应明,王中秀,雷利红,陈莉丽()
浙江大学医学院附属第二医院牙周病专科，浙江 杭州 310009
Global burden of periodontal disease and its relation with socioeconomic development during 1990—2019
WEI Yingming,WANG Zhongxiu,LEI Lihong,CHEN Lili()
Department of Periodontics, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
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摘要：

目的：基于伤残调整生命年（DALY）描述全球牙周病流行病学负担，并评估由社会经济发展水平差异造成的流行病学负担不公平情况。方法：从全球健康数据交换中心（GHDx）和人类发展报告获取1990—2019年全球和各国基于牙周病的年龄标化DALY率以及人类发展指数（HDI）。描述1990—2019年全球牙周病流行病学负担变化情况，采用线性回归分析2019年年龄标化DALY率与HDI的相关性，使用基尼系数和集中指数评价1990—2019年全球牙周病流行病学负担不公平情况及发展趋势。结果：1990—2019年，全球牙周病导致的年龄标化DALY率从78.63上升至85.48，牙周病流行病学负担未出现显著增长。2019年，牙周病年龄标化DALY率在不同社会经济发展水平国家间差异存在统计学意义（χ2=44.315，P<0.01）。线性回归分析进一步表明，牙周病年龄标化DALY率与HDI呈负相关（β=-0.417，P<0.01）。1990—2019年，全球牙周病流行病学负担基尼系数从0.361减少至0.281，集中指数从0.0339下降至-0.0538。结论：1990—2019年，全球牙周病流行病学负担虽未显著增长，但存在由社会经济水平差异造成的不公平现象。牙周病流行病学负担更集中于低社会经济发展水平国家，且自2000年后不公平程度呈加重趋势。
关键词： 牙周病;  流行病学负担;  伤残调整生命年;  人类发展指数;  基尼系数;  集中指数    
Abstract:

Objective: To analyze the global burden of periodontal disease and its relation with socioeconomic development. Methods: Data of global disability-adjusted life year (DALY) due to periodontal disease and human development index (HDI) from 1990 to 2019 were obtained from Global Health Data Exchange (GHDx) and human development reports. The trend of the global burden of periodontal disease from 1990 to 2019 was described. The correlation between age-standardized DALY rates and HDI were examined in 2019, and between-country periodontal disease burden inequality from 1990 to 2019 was measured using health-related Gini coefficients and concentration indexes. Results: From 1990 to 2019, the global DALY rate due to periodontal disease increased from 78.63 to 85.48, and the epidemiological burden did not increase significantly. Statistical differences were found across different HDI categories for age-standardized DALY rates of periodontal disease (χ2 =44.315, P<0.01) in 2019. Linear regression analysis also revealed a negative correlation between age-standardized DALY rate of periodontal disease and HDI (β = -0.417, P<0.01) . Gini coefficients decreased from 0.361 to 0.281 and concentration indexes fell from 0.0339 to -0.0538 between 1990 and 2019.Conclusions: The global burden of periodontal disease did not increase between 1990 and 2019, though the socioeconomic-associated inequality still existed. The burden of periodontal disease was more concentrated in less developed countries, and the socioeconomic-associated inequality has increased since 2000.
Key words: Periodontal disease    Epidemiological burden    Disability-adjusted life year    Human development index    Gini coefficient    Concentration index
收稿日期: 2021-01-04 出版日期: 2021-12-29
:  R780.1  
基金资助: 国家自然科学基金（81771072）； 浙江省重点研发计划（2019C03027）
通讯作者: 陈莉丽     E-mail: chenlili_1030@zju.edu.cn
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引用本文:

韦应明,王中秀,雷利红,陈莉丽. 1990—2019年全球牙周病流行病学负担及社会经济差异所致负担不公平程度分析[J]. 浙江大学学报（医学版）, 2021, 50(5): 545-552.

WEI Yingming,WANG Zhongxiu,LEI Lihong,CHEN Lili. Global burden of periodontal disease and its relation with socioeconomic development during 1990—2019. J Zhejiang Univ (Med Sci), 2021, 50(5): 545-552.

链接本文:

https://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2021-0321    或    https://www.zjujournals.com/med/CN/Y2021/V50/I5/545

图 1  1990—2019年全球牙周病年龄标化DALY率变化灰色阴影区域表示95%不确定区间. DALY：伤残调整生命年.
图 2  不同社会经济发展水平国家的牙周病年龄标化DALY率比较<0.05. DALY：伤残调整生命年.
图 3  各国牙周病年龄标化DALY率与HDI的线性回归图（=187）nDALY：伤残调整生命年；HDI：人类发展指数.
图 4  1990—2019年全球牙周病流行病学负担基尼系数变化趋势
图 5  1990—2019年全球牙周病流行病学负担集中指数变化趋势
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