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浙江大学学报(医学版)  2021, Vol. 50 Issue (6): 777-782    DOI: 10.3724/zdxbyxb-2021-0180
综述     
微单倍型在法医遗传学中的研究进展
周靖1,王艳1,徐恩萍1,2,*()
1.浙江大学基础医学院病理学与病理生理学系,浙江 杭州 310058
2.浙江大学司法鉴定中心,浙江 杭州 310029
Research progress on application of microhaplotype in forensic genetics
ZHOU Jing1,WANG Yan1,XU Enping1,2,*()
1.?Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Zhejiang University, Hangzhou 310058, China;
2. Forensic Science Center, Zhejiang University, Hangzhou 310029, China
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摘要:

微单倍型是一种可以应用于法医遗传学的新型遗传标记,具有多态性高、突变率低、无stutter产物、扩增片段短的特点。微单倍型可以有效检出混合斑,并对混合斑贡献者定量分析;对严重碎片化的DNA成功分型,应用于降解检材;作为始祖信息位点将全球大陆人群按照遗传结构进行有效划分;提供比短串联重复更多的信息量,帮助鉴定复杂亲缘关系;还可以为肿瘤身源鉴定、细胞系鉴定、产前亲子鉴定提供新的思路,因此具有非常广阔的应用前景。本文就微单倍型的上述应用方向进行论述,以期为法医学实践提供参考。

关键词: 法医遗传学微单倍型生物学物证混合斑降解检材种族推断复杂亲缘关系综述    
Abstract:

As a novel genetic marker, microhaplotype can be applied in the field of forensic genetics. Microhaplotype has the advantages of high polymorphism, low mutation rate, no stutter products and short amplification fragments. Microhaplotype can effectively detect mixture, and quantitatively analyze the contributors of mixture. DNA with severe fragmentation can be successfully genotyped by microhaplotype. It can be used as ancestry informative marker to effectively divide the global continental population according to genetic structure. Microhaplotype system can provide more information than traditional short tandem repeat and help to identify complex relationships. It can provide new ideas for tumor source identification, cell line identification and prenatal paternity testing. Here we review the applications of microhaplotype, intending to provide references for forensic practice.

Key words: Forensic genetics    Microhaplotype    Biological evidence    DNA mixture    Degraded DNA    Ancestry inference    Complex kinship testing    Review
收稿日期: 2021-06-29 出版日期: 2022-03-22
CLC:  R89  
基金资助: 浙江省公益性技术应用研究计划(LGF21H230001,2016C33150);浙江省自然科学基金(LY17H160025)
通讯作者: 徐恩萍     E-mail: xep@zju.edu.cn
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引用本文:

周靖,王艳,徐恩萍. 微单倍型在法医遗传学中的研究进展[J]. 浙江大学学报(医学版), 2021, 50(6): 777-782.

ZHOU Jing,WANG Yan,XU Enping. Research progress on application of microhaplotype in forensic genetics. J Zhejiang Univ (Med Sci), 2021, 50(6): 777-782.

链接本文:

https://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2021-0180        https://www.zjujournals.com/med/CN/Y2021/V50/I6/777

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