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浙江大学学报（医学版）
浙江大学学报（医学版）  2021, Vol. 50 Issue (3): 403-408    DOI: 10.3724/zdxbyxb-2021-0163
综述     
线粒体沉默信息调节因子家族在癫痫发生发展中的作用研究进展
朱锋1(),项迎春2,曾玲晖1,*()
1.浙大城市学院医学院，浙江 杭州 310015
2.浙江医院药剂科，浙江 杭州 310012
Progress on mitochondrial silence information regulator family in epilepsy
ZHU Feng1(),XIANG Yingchun2,ZENG Linghui1,*()
1. School of Medicine, Zhejiang University City College, Hangzhou 310015, China;
2. Department of Pharmacy, Zhejiang Hospital, Hangzhou 310012 ,China
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摘要：

线粒体沉默信息调节因子（sirtuin）包括SIRT3、SIRT4和SIRT5，在细胞寿命、细胞凋亡、基因组稳定性和代谢等进程中发挥重要的作用。SIRT3、SIRT4和SIRT5参与保护应激状态下线粒体的完整性，维持其能量代谢，调节脑内神经递质受体、神经营养因子、细胞外基质蛋白及各种转录调节因子表达，在遗传或获得性癫痫的发生发展中起重要作用。本文回顾了近年来线粒体sirtuin家族在癫痫发病机制中的研究进展，同时针对以线粒体sirtuin为治疗靶点的相关问题进行总结并展望，为进一步研究线粒体sirtuin功能和临床应用提供依据。
关键词： 线粒体;  沉默信息调节因子;  癫痫;  氧化应激;  机制;  综述    
Abstract:

SIRT3, SIRT4 and SIRT5 are located in mitochondria and also known as mitochondrial sirtuins. They play important roles in regulating many cellular functions including cell survival, cell cycle or apoptosis, DNA repair and metabolism. Mitochondrial sirtuins are involved in the protection of mitochondrial integrity and energy metabolism under stress regulating the expression of neurotransmitter receptors, neurotrophins, extracellular matrix proteins and various transcription factors, thus involved in epileptogenesis triggered by both genetic or acquired factors. Here we review research progress on the actions of mitochondrial sirtuin in epilepsy; and discuss the challenges and perspectives of mitochondrial sirtuin as a potential therapeutic target for epilepsy.
Key words: Mitochondrion    Silence information regulator    Epilepsy    Oxidative stress    Mechanism    Review
收稿日期: 2020-10-20 出版日期: 2021-08-16
CLC:  R742.1  
基金资助: 浙江省自然科学基金（LY20H09002）；浙江省医药卫生科技计划（2020RC088）
通讯作者: 曾玲晖     E-mail: zhuf@zucc.edu.cn;zenglh@zucc.edu.cn
作者简介: 朱　锋，副教授，主要从事神经药理学研究；E-mail：zhuf@zucc.edu.cn；https：//orcid.org/0000-0002-3220-6762
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引用本文:

朱锋,项迎春,曾玲晖. 线粒体沉默信息调节因子家族在癫痫发生发展中的作用研究进展[J]. 浙江大学学报（医学版）, 2021, 50(3): 403-408.

ZHU Feng,XIANG Yingchun,ZENG Linghui. Progress on mitochondrial silence information regulator family in epilepsy. J Zhejiang Univ (Med Sci), 2021, 50(3): 403-408.

链接本文:

http://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2021-0163    或    http://www.zjujournals.com/med/CN/Y2021/V50/I3/403

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