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浙江大学学报（医学版）
浙江大学学报（医学版）  2021, Vol. 50 Issue (2): 222-228    DOI: 10.3724/zdxbyxb-2021-0124
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口腔扁平苔藓与自身免疫性甲状腺疾病共存的免疫机制探讨
王雅慧(),郝一龙,唐帆,陈谦明()
浙江大学医学院附属口腔医院浙江大学口腔医学院浙江省口腔疾病临床医学研究中心浙江省口腔生物医学重点实验室浙江大学癌症研究院，浙江 杭州 310006
Immune mechanisms involved in the coexistence of oral lichen planus and autoimmune thyroid diseases
WANG Yahui(),HAO Yilong,TANG Fan,CHEN Qianming()
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, China
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摘要：

口腔扁平苔藓（OLP）是一种病因尚未完全明确的慢性炎症性口腔黏膜疾病。自身免疫性甲状腺疾病（AITD）是一类以甲状腺特异性抗体异常增多为特点的自身免疫性疾病。近年来，越来越多的研究表明，临床上 OLP 患者伴发 AITD 的概率呈上升趋势。两者的发生发展可能与口腔角质形成细胞表达甲状腺自身抗原、辅助性 T 细胞（Th）1/Th2 和 Th17/调节性T 细胞亚群的失衡、滤泡 Th 细胞和趋化因子数量及功能异常以及 CD8+ T 细胞特异性杀伤靶细胞等有关。本文就 OLP 与 AITD 可能共存的免疫机制作一综述，以期从免疫学角度为两者的诊疗提供思路。
关键词： 口腔扁平苔藓;  自身免疫性甲状腺疾病;  桥本甲状腺炎;  格雷夫斯病;  发病机制;  免疫学    
Abstract:

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease with unclear etiology. Autoimmune thyroid diseases (AITD) is a type of autoimmune disease characterized by increased thyroid-specific antibodies. In recent years, more and more studies have found that the incidence of AITD is increased in OLP patients. The occurrence and development of OLP and AITD may be related to the expression of thyroid autoantigen in oral keratinocytes, the imbalance of thyroid hormone （Th）1/Th2 and Th17/Treg cell subsets, the abnormal quantity and function of follicular helper T cells and chemokines and the specific killing ability of CD8+ T cells to target cells. In this article, the possible immune mechanisms involved in the coexistence of OLP and AITD are reviewed to provide insights for the diagnosis, treatment and prevention of these two diseases from the perspective of immunology.
Key words: Oral lichen planus    Autoimmune thyroid disease    Hashimoto disease    Graves disease    Pathogenesis    Immunology
收稿日期: 2021-02-01 出版日期: 2021-06-18
CLC:  R781.5  
基金资助: 国家自然科学基金创新研究群体项目（82001047）； 浙江省重点研发计划（2021C03074）
通讯作者: 陈谦明     E-mail: yhwang9703@163.com;qmchen@zju.edu.cn
作者简介: 王雅慧，硕士研究生，主要从事口腔黏膜病的病因与防治的研究；E-mail：yhwang9703@163.com；https：//orcid.org/0000-0002-9776-2057
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引用本文:

王雅慧,郝一龙,唐帆,陈谦明. 口腔扁平苔藓与自身免疫性甲状腺疾病共存的免疫机制探讨[J]. 浙江大学学报（医学版）, 2021, 50(2): 222-228.

WANG Yahui,HAO Yilong,TANG Fan,CHEN Qianming. Immune mechanisms involved in the coexistence of oral lichen planus and autoimmune thyroid diseases. J Zhejiang Univ (Med Sci), 2021, 50(2): 222-228.

链接本文:

http://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2021-0124    或    http://www.zjujournals.com/med/CN/Y2021/V50/I2/222

图 1  口腔扁平苔藓与自身免疫性甲状腺疾病相关联的免疫学机制
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