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浙江大学学报（医学版）
浙江大学学报（医学版）  2021, Vol. 50 Issue (2): 261-266    DOI: 10.3724/zdxbyxb-2021-0117
综述     
微藻在生物医学领域的研究进展
任超杰1(),钟丹妮2,*(),周民1,2,*()
1.浙江大学医学院附属第二医院，浙江 杭州 310009
2.浙江大学转化医学研究院，浙江 杭州 310029
Research progress on the biomedical application of microalgae
REN Chaojie1(),ZHONG Danni2,*(),ZHOU Min1,2,*()
1. the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China;
2. Institute of Translational Medicine, Zhejiang University, Hangzhou 310029, China
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摘要：

微藻作为一种自然界中丰富的天然生物材料之一，品种繁多，极易获取，在生物医学领域有着广泛的应用前景。微藻富含天然荧光素，可作为荧光成像和光声成像造影剂应用于医学成像；微藻活性表面可有效吸附功能分子、金属元素等，在药物递送领域有较好的应用前景；微藻能够通过光合作用产氧来提高局部氧气浓度，改善局部乏氧状态，以提高乏氧肿瘤疗效并促进伤口愈合。此外，微藻具有良好的生物相容性和生物安全性，具有较高的转化价值。本文将从生物成像、药物递送、乏氧肿瘤治疗和伤口愈合等方面介绍微藻在生物医学领域应用的最新研究进展。
关键词： 微藻;  生物成像;  药物递送;  乏氧肿瘤治疗;  伤口愈合;  综述    
Abstract:

Microalgae is an easy-to-obtain natural biological material with many varieties and abundant natural reserves. Microalgae are rich in natural fluorescein, which can be used as a contrast agent for fluorescence imaging and photoacoustic imaging for medical imaging. With its active surface, microalgae can effectively adsorb functional molecules, metal elements, etc., and have good application prospects in the field of drug delivery. Microalgae can generate oxygen through photosynthesis to increase local oxygen concentration, reverse local hypoxia to enhance the efficacy of hypoxic tumors and promote wound healing. In addition, microalgae have good biocompatibility, and different administration methods have no obvious toxicity. This paper reviews the research progress on the biomedical application of microalgae in bioimaging, drug delivery, hypoxic tumor treatment, wound healing.
Key words: Microalgae    Bioimaging    Drug delivery    Hypoxic tumor therapy    Wound healing    Review
收稿日期: 2021-01-26 出版日期: 2021-06-18
CLC:  Q81  
基金资助: 国家自然科学基金（81971667）；国家重点研发计划（2018YFC0115701）
通讯作者: 钟丹妮,周民     E-mail: rcj@zju.edu.cn;11718308@zju.edu.cn
作者简介: 任超杰，博士研究生，主要从事微藻相关研究；E-mail：rcj@zju.edu.cn；https：//orcid.org/0000-0002-9889-4756
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引用本文:

任超杰,钟丹妮,周民. 微藻在生物医学领域的研究进展[J]. 浙江大学学报（医学版）, 2021, 50(2): 261-266.

REN Chaojie,ZHONG Danni,ZHOU Min. Research progress on the biomedical application of microalgae. J Zhejiang Univ (Med Sci), 2021, 50(2): 261-266.

链接本文:

http://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2021-0117    或    http://www.zjujournals.com/med/CN/Y2021/V50/I2/261

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