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瞬时受体电位 M2抑制剂 A10对缺糖缺氧后复糖复氧细胞的保护作用 |
黄卓群1( ),余夏飞2,刘星宇2,马康3,黄敏华2,李芳芳2,杨巍2,*( ),牛建国1,3 |
1. 宁夏医科大学宁夏颅脑疾病重点实验室,宁夏 银川 750004 2. 浙江大学基础医学院生物物理学系,浙江 杭州 310058 3. 宁夏医科大学基础医学院人体解剖与组织胚胎学系,宁夏 银川 750004 |
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Protective effect of transient receptor potential melastatin 2 inhibitor A10 on oxygen glucose deprivation/reperfusion model |
HUANG Zhuoqun1( ),YU Xiafei2,LIU Xingyu2,MA Kang3,HUANG Minghua2,LI Fangfang2,YANG Wei2,*( ),NIU Jianguo1,3 |
1. Laboratory of Brain,Ningxia Medical University,Yinchuan 750004,China; 2. Department of Biophysics,Zhejiang University School of Medicine,Hangzhou 310058,China; 3. Department of Human Anatomy,Histology and Embryology,School of Basic Medicine,Ningxia Medical University,Yinchuan 750004,China |
引用本文:
黄卓群,余夏飞,刘星宇,马康,黄敏华,李芳芳,杨巍,牛建国. 瞬时受体电位 M2抑制剂 A10对缺糖缺氧后复糖复氧细胞的保护作用[J]. 浙江大学学报(医学版), 2021, 50(1): 106-112.
HUANG Zhuoqun,YU Xiafei,LIU Xingyu,MA Kang,HUANG Minghua,LI Fangfang,YANG Wei,NIU Jianguo. Protective effect of transient receptor potential melastatin 2 inhibitor A10 on oxygen glucose deprivation/reperfusion model. J Zhejiang Univ (Med Sci), 2021, 50(1): 106-112.
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http://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2021-0044
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http://www.zjujournals.com/med/CN/Y2021/V50/I1/106
|
1 |
YU C Z, LI C, PEI D S, et al. Neuroprotection against transient focal cerebral ischemia and oxygen–glucose deprivation by interference with GluR6-PSD 95 protein interaction[J] . Neurochem Res, 2009, 34(11): 2008-2021.
doi: 10.1007/s11064-009-9990-z
|
2 |
BAK S W, CHOI H, PARK H H, et al. Neuroprotective effects of acetyl-L-carnitine against oxygen-glucose deprivation-induced neural stem cell death[J]. Mol Neurobiol, 2016, 53(10): 6644-6652.
doi: 10.1007/s12035-015-9563-x
|
3 |
ZHAN K, YU P, LIU C, et al. Detrimental or beneficial:the role of TRPM2 in ischemia/reperfusion injury[J]. Acta Pharmacol Sin, 2016, 37(1): 4-12.
doi: 10.1038/aps.2015.141
|
4 |
BEHROUZIFAR S, VAKILI A, BANDEGI A R, et al. Neuroprotective nature of adipokine resistin in the early stages of focal cerebral ischemia in a stroke mouse model[J]. Neurochem Int, 2018, 99-107.
doi: 10.1016/j.neuint.2018.02.001
|
5 |
FONFRIA E, MURDOCK P R, CUSDIN F S, et al. Tissue distribution profiles of the human TRPM cation channel family[J]. J Recept Signal Transduct Res, 2006, 26(3): 159-178.
|
6 |
BELROSE J C, JACKSON M F . TRPM2:a candidate therapeutic target for treating neurological diseases[J]. Acta Pharmacol Sin, 2018, 39(5): 722-732.
doi: 10.1038/aps.2018.31
|
7 |
KANEKO S, KAWAKAMI S, HARA Y, et al. A critical role of TRPM2 in neuronal cell death by hydrogen peroxide[J]. J Pharmacol Sci, 2006, 101(1): 66-76.
doi: 10.1254/jphs.fp0060128
|
8 |
JIA J, VERMA S, NAKAYAMA S, et al. Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke[J]. J Cereb Blood Flow Metab, 2011, 31(11): 2160-2168.
doi: 10.1038/jcbfm.2011.77
|
9 |
HUANG S, TURLOVA E, LI F, et al. Transient receptor potential melastatin 2 channels (TRPM2) mediate neonatal hypoxic-ischemic brain injury in mice[J]. Exp Neurology, 2017, 32-40.
doi: 10.1016/j.expneurol.2017.06.023
|
10 |
ZHANG H, LIU H, LUO X, et al. Design,synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors[J]. Eur J Medicinal Chem, 2018, 235-252.
doi: 10.1016/j.ejmech.2018.04.045
|
11 |
CLAPHAM D E . TRP channels as cellular sensors[J]. Nature, 2003, 426(6966): 517-524.
doi: 10.1038/nature02196
|
12 |
NAGAMINE K, KUDOH J, MINOSHIMA S, et al. Molecular cloning of a novel putative Ca 2+ channel protein (TRPC7) highly expressed in brain[J] . Genomics, 1998, 54(1): 124-131.
doi: 10.1006/geno.1998.5551
|
13 |
MCHUGH D, FLEMMING R, XU S Z, et al. Critical intracellular Ca 2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation[J] . J Biol Chem, 2003, 278(13): 11002-11006.
doi: 10.1074/jbc.M210810200
|
14 |
YAMAMOTO S, SHIMIZU S, KIYONAKA S, et al. TRPM2-mediated Ca 2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration[J] . Nat Med, 2008, 14(7): 738-747.
doi: 10.1038/nm1758
|
15 |
GAO G, WANG W, TADAGAVADI R K, et al. TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1[J]. J Clin Invest, 2014, 124(11): 4989-5001.
doi: 10.1172/JCI76042
|
16 |
HERSON P S, LEE K, PINNOCK R D, et al. Hydrogen peroxide induces intracellular calcium overload by activation of a non-selective cation channel in an insulin-secreting cell line[J]. J Biol Chem, 1999, 274(2): 833-841.
doi: 10.1074/jbc.274.2.833
|
17 |
SONG K, WANG H, KAMM G B, et al. The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia[J]. Science, 2016, 353(6306): 1393-1398.
doi: 10.1126/science.aaf7537
|
18 |
HERMOSURA M C, CUI A M, GO R C V, et al. Altered functional properties of a TRPM2 variant in Guamanian ALS and PD[J] . Proc Natl Acad Sci USA, 2008, 105(46): 18029-18034.
doi: 10.1073/pnas.0808218105
|
19 |
FONFRIA E, MARSHALL I C B, BOYFIELD I, et al. Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures[J]. J Neurochem, 2005, 95(3): 715-723.
doi: 10.1111/j.1471-4159.2005.03396.x
|
20 |
VERMA S, QUILLINAN N, YANG Y F, et al. TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death[J] . NeuroSci Lett, 2012, 530(1): 41-46.
doi: 10.1016/j.neulet.2012.09.044
|
21 |
YE M, YANG W, AINSCOUGH J F, et al. TRPM2 channel deficiency prevents delayed cytosolic Zn 2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia[J/OL] . Cell Death Dis, 2014, 5(11): e1541.
doi: 10.1038/cddis.2014.494
|
22 |
RUIZ A, MATUTE C, ALBERDI E . Endoplasmic reticulum Ca 2+ release through ryanodine and IP3 receptors contributes to neuronal excitotoxicity[J] . Cell Calcium, 2009, 46(4): 273-281.
doi: 10.1016/j.ceca.2009.08.005
|
23 |
SHADEL G S, HORVATH T L . Mitochondrial ROS signaling in organismal homeostasis[J]. Cell, 2015, 163(3): 560-569.
doi: 10.1016/j.cell.2015.10.001
|
24 |
SZABADKAI G, DUCHEN M R . Mitochondria:the hub of cellular Ca 2+ signaling[J] . Physiology, 2008, 23(2): 84-94.
doi: 10.1152/physiol.00046.2007
|
25 |
GREEN D R, GALLUZZI L, KROEMER G . Metabolic control of cell death[J]. Science, 2014, 345(6203): 1250256.
doi: 10.1126/science.1250256
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