专题报道 |
|
|
|
|
手术创伤及多次丙泊酚麻醉对发育期大鼠神经发育和认知功能的影响 |
李扬1( ),李伟光2,冯泽国3,*( ),宋杰4,张成岗2,黄连军1,宋燕平4 |
1.中国人民解放军总医院第一医学中心麻醉手术中心,北京 100853 2.中国人民解放军军事科学院军事医学研究院辐射医学研究所,北京 100850 3.中国人民解放军总医院第一医学中心疼痛科,北京 100853 4.解放军医学院,北京 100853 |
|
Effect of operative trauma and multiple propofol anesthesia on neurodevelopment and cognitive function in developmental rats |
LI Yang1( ),LI Weiguang2,FENG Zeguo3,*( ),SONG Jie4,ZHANG Chenggang2,HUANG Lianjun1,SONG Yanping4 |
1. Anesthesia and Operation Center, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China; 2. Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China; 3. Department of Pain Management, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China; 4. Medical School of Chinese PLA, Beijing 100853, China |
引用本文:
李扬,李伟光,冯泽国,宋杰,张成岗,黄连军,宋燕平. 手术创伤及多次丙泊酚麻醉对发育期大鼠神经发育和认知功能的影响[J]. 浙江大学学报(医学版), 2021, 50(3): 290-297.
LI Yang,LI Weiguang,FENG Zeguo,SONG Jie,ZHANG Chenggang,HUANG Lianjun,SONG Yanping. Effect of operative trauma and multiple propofol anesthesia on neurodevelopment and cognitive function in developmental rats. J Zhejiang Univ (Med Sci), 2021, 50(3): 290-297.
链接本文:
http://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2021-0004
或
http://www.zjujournals.com/med/CN/Y2021/V50/I3/290
|
1 |
FDA. FDA Drug Safety Communication: FDA review results in new warnings about using general anesthetics and sedation drugs in young children and pregnant women[EB/OL]. (2017-04-28)[2017-11-07]. https://www.fda.gov/Drugs/DrugSafety/ucm532356.htm
|
2 |
李 扬, 李伟光, 冯泽国, 等. 丙泊酚及手术创伤对发育期大鼠神经发育和认知功能的影响[J]. 南方医科大学学报, 2018, 38(2): 187-191 LI Yang, LI Weiguang, FENG Zeguo, et al. Effect of propofol and operative trauma on neurodevelopment and cognitive function of developing brain in rats[J]. Journal of Southern Medical University, 2018, 38(2): 187-191. (in Chinese)
|
3 |
CATTANOD, YOUNGC, STRAIKOM M W, et al.Subanesthetic doses of propofol induce neuroapoptosis in the infant mouse brain[J]Anesth Analg, 2008, 106( 6): 1712-1714.
doi: 10.1213/ane.0b013e318172ba0a
|
4 |
YUD, JIANGY, GAOJ, et al.Repeated exposure to propofol potentiates neuroapoptosis and long-term behavioral deficits in neonatal rats[J]Neurosci Lett, 2013, 41-46.
doi: 10.1016/j.neulet.2012.12.033
|
5 |
NYMANY, FREDRIKSSONA, L?NNQVISTP A, et al.Etomidate exposure in early infant mice (P10) does not induce apoptosis or affect behaviour[J]Acta Anaesthesiol Scand, 2016, 60( 5): 588-596.
doi: 10.1111/aas.12685
|
6 |
ROMIJNH J, HOFMANM A, GRAMSBERGENA. At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby?[J]Early Hum Dev, 1991, 26( 1): 61-67.
doi: 10.1016/0378-3782(91)90044-4
|
7 |
SENGUPTA P. The laboratory rat: relating its age with human’s[J]. Int J Prev Med, 2013, 4(6): 624-630
|
8 |
MAD, WILLIAMSONP, JANUSZEWSKIA, et al.Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain[J]Anesthesiology, 2007, 106( 4): 746-753.
doi: 10.1097/01.anes.0000264762.48920.80
|
9 |
YIRMIYAR, GOSHENI. Immune modulation of learning, memory, neural plasticity and neurogenesis[J]Brain Behav Immun, 2011, 25( 2): 181-213.
doi: 10.1016/j.bbi.2010.10.015
|
10 |
都义日, 刘 斌, 郎海云, 等. 乌司他丁对手术创伤致大鼠术后认知功能障碍的影响及相关机制研究[J]. 河北医科大学学报, 2019, 40(7): 842-846 DU Yiri, LIU Bin, LANG Haiyun, et al. Effects of ulinastatin on postoperative cognitive dysfunction and related mechanisms in rats after surgical trauma[J]. Journal of Hebei Medical University, 2019, 40(7): 842-846. (in Chinese)
|
11 |
FIDALGOA R, CIBELLIM, WHITEJ P M, et al.Peripheral orthopaedic surgery down-regulates hippocampal brain-derived neurotrophic factor and impairs remote memory in mouse[J]Neuroscience, 2011, 194-199.
doi: 10.1016/j.neuroscience.2011.05.073
|
12 |
FIDALGOA R, CIBELLIM, WHITEJ P M, et al.Systemic inflammation enhances surgery-induced cognitive dysfunction in mice[J]Neurosci Lett, 2011, 498( 1): 63-66.
doi: 10.1016/j.neulet.2011.04.063
|
13 |
WURIG, WANGD X, ZHOUY, et al.Effects of surgical stress on long-term memory function in mice of different ages[J]Acta Anaesthesiol Scand, 2011, 55( 4): 474-485.
doi: 10.1111/j.1399-6576.2011.02402.x
|
14 |
姚 星, 彭 勉, 鲁胜强, 等. 手术创伤对老龄大鼠海马炎症介质表达的影响[J]. 武汉大学学报(医学版), 2013, 34(2): 171-173 YAO Xing, PENG Mian, LU Shengqiang, et al. Effects of surgical trauma on the expression of inflammatory mediators in the hippocampus of aged rats[J]. Medical Journal of Wuhan University, 2013, 34(2): 171-173. (in Chinese)
|
15 |
VARELIK, FRANGOU-LAZARIDISM. Prothymosin α is localized in mitotic spindle during mitosis[J]Biol Cell, 2004, 96( 6): 421-428.
doi: 10.1016/j.biolcel.2004.04.002
|
16 |
童民锋, 刘伟国. c-fos基因在大鼠创伤性颅脑损伤中不同阶段表达水平与细胞凋亡关系的研究[J]. 浙江创伤外科, 2009, 14(5): 432-433 TONG Minfeng, LIU Weiguo. Study on the expression of c-fos on different stages after traumatic brain injury and the relationship between the expression and apoptosis after head trauma[J]. Zhejiang Journal of Traumatic Surgery, 2009, 14(5): 432-433. (in Chinese)
|
17 |
YIN C, GOU L S, LIU Y, et al. Repeated administration of propofol upregulated the expression of c-Fos and cleaved-caspase-3 proteins in the developing mouse brain[J]. Indian J Pharmacol, 2011, 43(6): 648-651
|
18 |
陈延福, 金先庆, 杨 坤, 等. 丙泊酚、神经节苷脂对幼鼠认知和caspase-3表达的影响[J]. 解放军医学杂志, 2010, 35(7): 845-848 CHEN Yanfu, JIN Xianqing, YANG Kun, et al. Effect of propofol and monosialoterahexosyl ganglioside on cognitive function and the expression of caspase-3 in immature rats[J]. Medical Journal of Chinese People’s Liberation Army, 2010, 35(7): 845-848. (in Chinese)
|
19 |
YOUNG C, OLNEY J W. Neuroapoptosis in the infant mouse brain triggered by a transient small increase in blood alcohol concentration[J]. Neurobiol Dis, 2006, 22(3): 548-554
|
20 |
PRESTONG A, LYONT T, YINY, et al.Induction of apoptosis by c-Fos protein[J]Mol Cell Biol, 1996, 16( 1): 211-218.
doi: 10.1128/mcb.16.1.211
|
21 |
MILANOVICD, PESICV, LONCAREVIC-VASILJKOVICN, et al.The Fas ligand/fas death receptor pathways contribute to propofol-Induced apoptosis and neuroinflammation in the brain of neonatal rats[J]Neurotox Res, 2016, 30( 3): 434-452.
doi: 10.1007/s12640-016-9629-1
|
22 |
KARENT, SCHLAGERG W, BENDIXI, et al.Effect of propofol in the immature rat brain on short- and long-term neurodevelopmental outcome[J/OL]PLoS One, 2013, 8( 5): e64480.
doi: 10.1371/journal.pone.0064480
|
23 |
GAOJ, PENGS, XIANGS, et al.Repeated exposure to propofol impairs spatial learning, inhibits LTP and reduces CaMKIIα in young rats[J]Neurosci Lett, 2014, 62-66.
doi: 10.1016/j.neulet.2013.11.061
|
24 |
WANGY L, CHENX, WANGZ P. Detrimental effects of postnatal exposure to propofol on memory and hippocampal LTP in mice[J]Brain Res, 2015, 321-327.
doi: 10.1016/j.brainres.2015.06.044
|
25 |
高 进, 余得水, 胡 佳, 等. 丙泊酚对新生大鼠远期神经行为学的影响及机制[J]. 重庆医科大学学报, 2012, 37(4): 323-327 Gao Jin, YU Deshui, HU Jia, et al. Effects of Propofol on long-term neuroethology of neonatal rats and its mechanism[J]. Journal of Chongqing Medical University, 2012, 37(4): 323-327. (in Chinese)
|
26 |
STURMAND A, MOGHADDAMB. The neurobiology of adolescence: changes in brain architecture, functional dynamics, and behavioral tendencies[J]Neurosci BioBehav Rev, 2011, 35( 8): 1704-1712.
doi: 10.1016/j.neubiorev.2011.04.003
|
27 |
刘 雁, 董为伟. 中枢神经损伤修复及功能代偿[J]. 神经损伤与功能重建, 2006, 1(4):197-199 LIU Yan, DONG Weiwei. Central nerve injury repair and functional compensation[J]. Neural Injury and Functional Reconstruction, 2006, 1(4): 197-199. (in Chinese)
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|