A full-scale blasting experiment of adjacent pre-buried pipes was designed and implemented, aiming at the common direct-buried ductile iron pipes in the urban area of Wuhan. Combined with the finite element numerical calculation method and considering the different buried depth of the pipeline, the dynamic response of the directly buried pipeline in the silty clay layer under the action of the blasting vibration was studied. Results show that the pipeline and the surface peak particle velocities (PPVs) increase with the decrease of the blast distance, and the most dangerous working condition is blasting directly below the pipeline. The central section of the pipeline is dangerous. The PPVs at the waist and bottom of the tube are larger for the dangerous section. The dynamic strain is mainly the axial tensile strain and the hoop strain is smaller. The peak effective stress in the bottom element is the largest and that of the pipe shoulder is the smallest. There is a functional relationship between PPVS and different embedded depth of pipeline. By measuring the relationship between the surface PPVs and the peak effective stress, the peak effective stress of the pipeline section can be predicted, which provides a calculation method for the safety determination of related pipelines in engineering construction.