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浙江大学学报(工学版)
J4  2011, Vol. 45 Issue (12): 2216-2221    DOI: 10.3785/j.issn.1008-973X.2011.12.022
机械工程     
PCR热循环系统热性能影响因素的等效电路研究
黄靖, 陈章位, 姚英豪
浙江大学 流体传动及控制国家重点实验室,浙江 杭州 310027
Study on factors affecting thermal performance of
PCR thermal cycle system by equivalent circuit
HUANG Jing, CHEN Zhang-wei, YAO Ying-hao
State Key Laboratory of Fluid Power Transmission and Control, Zhejiang University, Hangzhou 310027, China
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摘要：

根据热电相似性理论,建立基于半导体制冷片的聚合酶链反应(PCR)热循环系统的等效电路模型,将系统中各部件的热参数等效替换成相应的电路参数.利用该模型,分别分析在加热和制冷模式下,驱动电流、散热器热阻和样品块材料等因素对PCR热循环系统热性能的影响程度,得到了在各工作状况下样品块温度的稳态和动态曲线.结果表明：当驱动电流取最佳值Im时，系统可获得最佳制冷效果；驱动电流越大或材料的热容越小,系统升降温速度越快；材料不同对系统的Im值无明显影响；散热器热阻越小,样品块温度稳态值越低,系统的Im值越大.在设计时选择低热容的材料、低热阻的散热器以及最佳Im,可使系统获得最佳的热性能.
Abstract:

According to the thermal-electric analogies, an equivalent circuit model of the polymerase chain reaction (PCR) thermal cycle system based on thermoelectric coolers was established. System thermal parameters were replaced by equivalent electric parameters. With the equivalent circuit model, the system thermal performance was analyzed in cooling and heating modes respectively with different facts, such as driving current, sample block material, and heat sink thermal resistance. The transient and steady curves of the sample block temperature under various operation conditions were obtained. The result show that the system can achieve optimal cooling performance at optimal driving current Im. The system heating and cooling rates are more rapid with larger driving current or smaller material thermal capacity. Different material has little impact on the value of Im. The steady values of sample block temperature is lower and Im has is larger with smaller heat sink thermal resistance. The optimal thermal performance of the PCR thermal cycle system is achieved by choosing sample black with low thermal capacity material, heat sink with low thermal resistance and driving current with optimal value.
出版日期: 2011-12-01
:  TH 79  
基金资助:

浙江省科技厅重大科技专项基金资助项目(2010C11022).
通讯作者: 陈章位, 男, 博士, 教授.     E-mail: chenzw@zju.edu.cn
作者简介: 黄靖(1985—), 男,博士生, 从事基因扩增分析仪器及其相关技术研究. E-mail: rickyhj@zju.edu.cn
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引用本文:

黄靖, 陈章位, 姚英豪. PCR热循环系统热性能影响因素的等效电路研究[J]. J4, 2011, 45(12): 2216-2221.

HUANG Jing, CHEN Zhang-wei, YAO Ying-hao. Study on factors affecting thermal performance of
PCR thermal cycle system by equivalent circuit. J4, 2011, 45(12): 2216-2221.

链接本文:

https://www.zjujournals.com/eng/CN/10.3785/j.issn.1008-973X.2011.12.022    或    https://www.zjujournals.com/eng/CN/Y2011/V45/I12/2216

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