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高校应用数学学报
Applied Mathematics A Journal of Chinese Universities  2017, Vol. 32 Issue (3): 343-352    DOI:
    
Pharmacokinetic model of digoxin in the treatment of fetal arrhythmia and its application
LI Dong-mei1, GUO Mei-jing1, WANG Qi2
1. Applied Science College, Harbin University of Science and Technology, Harbin 150080, China
2. Department of pediatrics Heilongjiang Hospital, Harbin 150056, China
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Abstract  In this paper, according to the dynamic change regulation of pregnant mother and fetus growth, a pharmacokinetic model of maternal fetal oral digoxin in the treatment of tachyarrhythmia is established, reasonable regimens on the basis of the gestational age changes and the digoxin therapeutic window of clinical react blood drug concentration are designed, and MATLAB program for simulation, analysising the feasibility of the scheme is used.

Key words： tachyarrhythmia      pharmacokinetic model      dosage of administration      medication regimen     
Received: 16 January 2017      Published: 07 April 2018
CLC:  O175  
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LI Dong-mei
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Cite this article:

LI Dong-mei, GUO Mei-jing, WANG Qi. Pharmacokinetic model of digoxin in the treatment of fetal arrhythmia and its application. Applied Mathematics A Journal of Chinese Universities, 2017, 32(3): 343-352.

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http://www.zjujournals.com/amjcua/     OR     http://www.zjujournals.com/amjcua/Y2017/V32/I3/343


地高辛治疗胎儿快速心律失常的药物动力学模型及其应用

针对孕母及胎儿生长的动态变化规律, 建立了通过孕母口服地高辛治疗胎儿快速心律失常的药物动力学模型, 根据胎龄变化及临床上地高辛的治疗窗口所反映的血药浓度, 设计了合理的用药方案, 并运用MATLAB程序进行应用模拟, 分析了方案的可行性.

关键词： 胎儿快速心律失常,  药物动力学模型,  给药剂量,  用药方案 
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