脊椎动物神经管背-腹图式形成中形态素的调控作用综述

刘聪,徐鹏飞

Review on regulatory role of morphogens in the formation of dorsal-ventral pattern of vertebrate neural tube

Cong LIU,Pengfei XU

图3 斑马鱼早期发育中BMP浓度梯度转换过程A.原肠胚初期，在背侧组织者分泌的BMP拮抗剂的作用下，胚胎中BMP信号形成从腹侧到背侧（从高到低）的浓度梯度。B.神经发生初期，由于胚胎的汇聚延伸运动，神经外胚层细胞迁移到背中线形成神经板，同时，神经板中线处开始内陷。此时，BMP信号在外侧浓度较高，在中线处浓度最低。C.当神经发生完成并形成神经管时，起源于原肠胚最腹侧的细胞迁移到神经管的最背侧，最终形成从背侧到腹侧（从高到低）的BMP浓度梯度。LV：侧视图；DV：背视图；AV：动物极视图；NP：神经板；NT：神经管（下同）。

Fig. 3 BMP concentration gradient shifting process during the zebrafish early developmentA. At the beginning of the gastrulation, the BMP antagonists secreted from the dorsal organizer result in a ventral to dorsal (high to low) BMP concentration gradient. B. At the beginning of the neurulation, because of the convergence and extension, the neuroectodermal cells migrate to the dorsal midline; at the same time, the neural plate forms. At this moment, the BMP concentration gradient is higher at the lateral, and the cells at the midline start to invaginate where the BMP concentration is the lowest. C. When the neurulation is completed and the neural tube is formed, the cells that originate from the most ventral side of the gastrula now migrate to the most dorsal side of the neural tube, where forms an eventual dorsal to ventral (high to low) BMP concentration gradient. LV: Lateral view; DV: Dorsal view; AV: Animal view; NP: Neural plate; NT: Neural tube (the same as below).