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| Extracellular HIV Tat and Tat cysteine rich peptide increase CCR5 expression in monocytes |
| ZHENG Lin, YANG Yi-da, LU Guo-cai, SALVATO Maria S. |
| Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Institute of Human Virology, University of Maryland Biotechnology Center, Baltimore, MD 21201, USA |
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Abstract In our previous work we reported that HIV Tat and 6 cysteine rich peptides of Tat induce tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in human monocytes (Yang et al., 2003). Here our results showed that HIV Tat and Tat cysteine rich peptide increase CCR5 expression in human monocytes, and this activity is inhibited by rabbit anti-Tat. Boiled Tat does not increase CCR5 expression in monocytes. These results provide insight into a new mechanism by which HIV Tat plays a key role in the pathogenesis of HIV-1 infection.
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Received: 01 June 2004
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