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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2015, Vol. 16 Issue (7): 632-639    DOI: 10.1631/jzus.B1400309
Articles     
Correlation analysis of gene polymorphisms and β-lactam allergy
Jing Li, Xin-yue Liu, Lin-jing Li, Chong-ge You, Lei Shi, Shang-di Zhang, Qian Liu, Jun Wang, Ze-jing Liu, Ting-hong Lv
Centre of Laboratory Medicine, Lanzhou University Second Hospital, Lanzhou 730030, China; School of Basic Medical Science, Lanzhou University, Lanzhou 730030, China
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Abstract  A total of 64 patients with β-lactam allergy and 30 control subjects were enrolled in a case-control study. This study is aimed to analyze the relationship between β-lactam allergy and 10 single nucleotide polymorphisms (SNPs) in interleukin-10 (IL-10), IL-13, IL-4Rα, high-affinity immunoglobulin E-receptor β chain (FcεRIβ), interferon γ receptor 2 (IFNGR2), and CYP3A4, and within the Han Chinese population of Northwest China. Genotyping for the SNPs was conducted using the Sequenom MassARRAY® platform. SPSS 17.0 was employed to analyze the statistical data and SHEsis was used to perform the haplotype reconstruction and analyze linkage disequilibrium of SNPs of IL-10 and IL-13. The results showed that the genotype distribution of CYP3A4 rs2242480/CT differed significantly between case and control groups of males (P=0.022; odds ratio (OR)=0.167, 95% confidence interval (CI): 0.032–0.867). Further analysis showed that CCA, CCG, and TAA haplotypes of IL-10 had no significant correlation in patients with β-lactam allergy. The correlation between CCT and CAC haplotypes of IL-13 and β-lactam allergy needs to be further studied. The analysis did not reveal any differences in the distribution of others gene polymorphisms between cases and controls.

Key words： Allergy      β-Lactam      Interleukin (IL)      Pharmacogenomics      Single nucleotide polymorphism (SNP)     
Received: 15 November 2014      Published: 03 July 2015
CLC:  R394.6  
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Jing Li
Ze-jing Liu
Ting-hong Lv
Xin-yue Liu
Lin-jing Li
Chong-ge You
Lei Shi
Shang-di Zhang
Qian Liu
Jun Wang
Cite this article:

Jing Li, Xin-yue Liu, Lin-jing Li, Chong-ge You, Lei Shi, Shang-di Zhang, Qian Liu, Jun Wang, Ze-jing Liu, Ting-hong Lv. Correlation analysis of gene polymorphisms and β-lactam allergy. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(7): 632-639.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1400309     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2015/V16/I7/632

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