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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2013, Vol. 14 Issue (6): 505-510    DOI: 10.1631/jzus.B1200293
Articles     
β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation
Xiao-jing Zhao, Zhuo Pen, Ping Li, Er-xiu Chen, Jian Liu, Yan-xia Gao, Yun-xia Ren, Li-jun Li
Department of Emergency Medicine, the Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710004, China; Mechanical, Energy and Experimental Center of Medical College, Xi\'an Jiaotong University, Xi\'an 710068, China
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Abstract  Objective: We investigated the influence of β-receptor blocker metoprolol on return of spontaneous circulation (ROSC) during cardiopulmonary resuscitation (CPR) in rats with induced myocardial infarction (MI). Methods: Male Sprague-Dawley rats were randomly divided into three groups: the sham-operated group, the MI group without metoprolol, which was fed the vehicle, and the MI+metoprolol group receiving intragastric metoprolol. Each group was further divided randomly into three subgroups, depending on the dosage of epinephrine administered during subsequent CPR applied after the induction of asphyxial cardiac arrest. Results: The ROSC rate was significantly decreased in the low dose subgroup of MI group, unchanged in the medium dose subgroup of MI group, and significantly decreased in the high dose subgroup of MI group, compared with the same dose subgroup of sham-operated group. MI+metoprolol group had a lower ROSC rate than MI group in the medium dose subgroup, and a higher ROSC rate than MI group in the high dose subgroup. There was no difference in blood K+ values of successful rats between MI group and MI+metoprolol group. The rats with successful CPR had lower blood K+ values than rats with unsuccessful CPR in each of the three treatment groups. Conclusions: Metoprolol administered to MI rats over a long period significantly improved ROSC rates under an appropriate dose of epinephrine during CPR. An increasing high blood K+ value would attenuate the rate of a successful CPR.

Key words： β-receptor blocker      Cardiopulmonary resuscitation      Return of spontaneous circulation      Epinephrine      Chemical examination     
Received: 28 October 2012      Published: 04 June 2013
CLC:  R541  
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Xiao-jing Zhao
Zhuo Pen
Ping Li
Er-xiu Chen
Jian Liu
Yan-xia Gao
Yun-xia Ren
Li-jun Li
Cite this article:

Xiao-jing Zhao, Zhuo Pen, Ping Li, Er-xiu Chen, Jian Liu, Yan-xia Gao, Yun-xia Ren, Li-jun Li. β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(6): 505-510.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1200293     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2013/V14/I6/505

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