Please wait a minute...
ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2011, Vol. 12 Issue (8): 660-667    DOI: 10.1631/jzus.B1101008
    
Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease
Chun-na Jin, Hong Ma, Yan Lin, Jian-an Wang, Mei-xiang Xiang
Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China, Cardiovascular Key Lab of Zhejiang Province, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Download:     PDF (0 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  Objective: The gene for mast cell chymase (CMA1) is an ideal candidate for investigating the genetic predisposition to coronary heart disease (CHD), as activated mast cells have been found to be present in a greater proportion in the shoulder region of atheroma than in normal coronary intimae. Previous studies have indicated that CMA1 promoter polymorphism rs1800875 may be involved in regulating immunoglobulin E (IgE) levels in patients with eczema, and it is associated with the progression of immunoglobulin A nephropathy. Methods: The association between single nucleotide polymorphism (SNP) rs1800875, serum chymase, and serum IgE levels was examined in 175 CHD subjects and 95 non-CHD subjects. Results: Statistical analysis indicated no significant difference in allele frequency between CHD and non-CHD. However, a significant association was found between CMA1 genotypes and total IgE levels in CHD subjects. Meanwhile, crossover analysis revealed that, in GG homozygotes, CHD risk was nearly six times higher in those with IgE (U/ml) level <2.58 (natural logarithm conversion), while no association was found with chymase level. Conclusions: Polymorphism rs1800875 of CMA1 may be associated with serum IgE level in CHD subjects, but not with chymase level in both groups. In GG homozygotes, high IgE level is a protective factor against coronary disease.

Key words： Coronary heart disease      CMA1      Serum immunoglobulin E (IgE)      Serum chymase     
Received: 30 June 2011      Published: 02 August 2011
CLC:  R543.3  
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
Chun-na Jin
Hong Ma
Yan Lin
Jian-an Wang
Mei-xiang Xiang
Cite this article:

Chun-na Jin, Hong Ma, Yan Lin, Jian-an Wang, Mei-xiang Xiang. Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2011, 12(8): 660-667.

URL:

http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1101008     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2011/V12/I8/660

[1] Hui-yong Peng, Chang-feng Man, Juan Xu, Yu Fan. Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(1): 78-86.
[2] Yan-jun Gong, Tao Hong, Jie Jiang, Rong-hui Yu, Yan Zhang, Zhao-ping Liu, Yong Huo. Influence of education and working background on physicians’ knowledge of secondary prevention guidelines for coronary heart disease: results from a survey in China[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(3): 231-238.
[3] Yong Huo. Current status and development of percutaneous coronary intervention in China[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2010, 11(8): 631-633.