| Biomedicine |
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| Plasticity of human menstrual blood stem cells derived from the endometrium |
| Jian Lin, Dennis Xiang, Jin-long Zhang, Julie Allickson, Charlie Xiang |
| State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China, Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA, Infectious Disease Unit, Zhejiang Armed Police Hospital, Jiaxing 314000, China, Cryo-Cell International Inc., Oldsmar, FL 34677, USA, S-Evans Biosciences, Hangzhou 311121, China, J. Craig Venter Institute, Rockville, MD 20850, USA |
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Abstract Stem cells can be obtained from women’s menstrual blood derived from the endometrium. The cells display stem cell markers such as Oct-4, SSEA-4, Nanog, and c-kit (CD117), and have the potent ability to differentiate into various cell types, including the heart, nerve, bone, cartilage, and fat. There has been no evidence of teratoma, ectopic formation, or any immune response after transplantation into an animal model. These cells quickly regenerate after menstruation and secrete many growth factors to display recurrent angiogenesis. The plasticity and safety of the acquired cells have been demonstrated in many studies. Menstrual blood-derived stem cells (MenSCs) provide an alternative source of adult stem cells for research and application in regenerative medicine. Here we summarize the multipotent properties and the plasticities of MenSCs and other endometrial stem cells from recent studies conducted both in vitro and in vivo.
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Received: 11 January 2011
Published: 06 May 2011
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