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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2011, Vol. 12 Issue (1): 12-17    DOI: 10.1631/jzus.B1000106
Biomedicine     
Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy
Barbara Ruszkowska, Gra?yna Gadomska, Liliana Bielis, Marzena Gruszka, Barbara Góralczyk, Danuta Ro??, Gra?yna Odrow??-Sypniewska
Department of Pathophysiology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, st. Marii Sk?odowskiej-Curie 9, 85-094 Bydgoszcz, Poland, Department of Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, st. Marii Sk?odowskiej-Curie 9, 85-094 Bydgoszcz, Poland
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Abstract  Objective: The influence of hormone replacement therapy (HRT) on hemostasis processes depends on the type of hormone, the combination of doses, the time of taking HRT, and the route of administration (oral, transdermal, implanted). The aim of the current study was to assess some parameters of coagulation, especially tissue factor pathway inhibitor (TFPI) and tissue factor (TF) in postmenopausal women using oral or transdermal HRT. Methods: The study was conducted on 76 healthy women, including 46 women aged 44–58 years who were taking oral (26) or transdermal (20) HRT, and 30 women aged 44–54 years who did not take HRT as the control group. Plasma concentrations of TF, TFPI, thrombin-antithrombin complex (TAT), and D-dimer were performed by enzyme-linked immunosorbent assay (ELISA). Moreover, the concentration of fibrinogen and activity of protein C were measured by chromogenic and chronometric methods. Results: We observed a significantly higher concentration of TF and a significantly lower concentration of TFPI in women taking oral and transdermal HRT in comparison with the control group. We also found a significantly lower concentration of fibrinogen in women taking oral HRT vs. the control group. Moreover, no statistically significant changes in concentrations of TAT and D-dimer, or activity of protein C were noted. Conclusions: In this study, the occurrence of an increased TF concentration simultaneously with a decreased concentration of TFPI in women taking HRT indicates hypercoagulability. No significant modification of TAT or D-dimer occurred, and thus there may not be increased risk of thrombosis.

Key words： Menopause      Coagulation      Hormone replacement therapy     
Received: 26 March 2010      Published: 06 January 2010
CLC:  R543  
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Liliana Bielis
Marzena Gruszka
Barbara Ruszkowska
Gra?yna Gadomska
Barbara Góralczyk
Danuta Ro??
Gra?yna Odrow??-Sypniewska
Cite this article:

Barbara Ruszkowska, Gra?yna Gadomska, Liliana Bielis, Marzena Gruszka, Barbara Góralczyk, Danuta Ro??, Gra?yna Odrow??-Sypniewska. Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2011, 12(1): 12-17.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1000106     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2011/V12/I1/12

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