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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2009, Vol. 10 Issue (4): 258-263    DOI: 10.1631/jzus.B0820261
Biotechnology     
Prebiotic oligosaccharides change the concentrations of short-chain fatty acids and the microbial population of mouse bowel
Xiao-dong PAN, Fen-qin CHEN, Tian-xing WU, Hong-gang TANG, Zhan-yu ZHAO
Department of Chemistry, Zhejiang University, Hangzhou 310027, China; College of Animal Sciences, Zhejiang University, Hangzhou 310027, China
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Abstract  The purpose of this study was to clarify effects of selected oligosaccharides on concentrations of cecal short-chain fatty acids (SCFAs), total large bowel wet weight and wall weight, and cecal microbiota levels in mice. Mice were respectively given gavage of selected fructooligosaccharides (FOS), galactooligosaccharides (GOS), mannanoligosaccharides (MOS), and chitooligosaccharides (COS) [1000 mg/(kg body weight·d)]. Control group was given physiological saline solution. After 14 d treatment, SCFAs and lactate in mice cecum were significantly increased (P<0.05) by intake of oligosaccharides, especially FOS and GOS. Thus, providing these oligosaccharides as ingredients in nutritional formulas may benefit the gastrointestinal tract.

Key words： Oligosaccharides      Short-chain fatty acids (SCFAs)      Bifidobacteria      Lactobacilli      Mouse     
Received: 25 August 2008     
CLC:  Q5  
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Xiao-dong PAN
Fen-qin CHEN
Tian-xing WU
Hong-gang TANG
Zhan-yu ZHAO
Cite this article:

Xiao-dong PAN, Fen-qin CHEN, Tian-xing WU, Hong-gang TANG, Zhan-yu ZHAO. Prebiotic oligosaccharides change the concentrations of short-chain fatty acids and the microbial population of mouse bowel. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2009, 10(4): 258-263.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0820261     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2009/V10/I4/258

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