Please wait a minute...
ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2007, Vol. 8 Issue (9): 620-625    DOI: 10.1631/jzus.2007.B0620
Biomedicine     
Effect of basic fibroblast growth factor (bFGF) on the treatment of exposure of the orbital implants
CUI Hong-guang, LI Hui-yan
Department of Ophthalmology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Download:     PDF (0 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  Objective: To evaluate the efficacy and the indication of basic fibroblast growth factor (bFGF) in the treatment of exposure of orbital implants. Design: Retrospective and observational case series. Methods: We reviewed 41 patients (41 eyes) suffering exposure of orbital implants from Jan. 2000 to June 2006. The study group patients with mild exposure received combined treatment with bFGF and antibiotic drops, and while the control group patients with mild exposure were treated with antibiotic drops only. The study group patients with moderate and severe exposure received combined treatment with bFGF and antibiotic drops, and after 2 months they were subjected to amniotic membrane transplantation, while the control group patients with moderate and severe exposure underwent amniotic membrane transplantation after using antibiotic drops. Observation of the growth of conjunctival epithelium and comparison of the healing rate of the two groups. Results: The healing rates of the mild, moderate and severe exposure study group were 100% and 92.3%. The healing rates of the mild, moderate and severe exposure control group were 55.6% and 66.7% respectively. The difference of the healing rates of the mild exposure study group and the control group was significant (P=0.033). And the difference of the healing rates of the moderate and severe exposure study group and the control group was not significant (P=0.167). Conclusion: bFGF may promote obviously the healing of orbital implant exposure, particularly it can be the first choice for the treatment of mild degree exposure. For the moderate and severe cases, it can be administered before surgical repair to enhance neovascularization and will tend to increase the success rate of surgical repair.

Key words： Exposure      Orbital implants      Basic fibroblast growth factor (bFGF)     
Received: 31 January 2007     
CLC:  R779.64  
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
CUI Hong-guang
LI Hui-yan
Cite this article:

CUI Hong-guang, LI Hui-yan. Effect of basic fibroblast growth factor (bFGF) on the treatment of exposure of the orbital implants. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2007, 8(9): 620-625.

URL:

http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2007.B0620     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2007/V8/I9/620

[1] Yi-na WANG, Hong FANG, Wei-fang ZHU. Survey on skin aging status and related influential factors in Southeast China[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2009, 10(1): 57-66.
[2] CHEN Yan-hong, CUI Hong-guang. Amniotic membrane transplantation for porous sphere orbital implant exposure[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2007, 8(9): 616-619.
[3] ZHANG Ying, YE Li-ping, WANG Biao, CAO Shi-cheng, SUN Li-guang. Effect of lead on ERK activity and the protective function of bFGF in rat primary culture astroglia[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2007, 8(6): 422-427.
[4] RAHMAN Sohaila, KHALID Nasir, ZAIDI Jamshed Hussain, AHMAD Shujaat, IQBAL Mohammad Zafar. Non-occupational lead exposure and hypertension in Pakistani adults[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2006, 7(9 ): 10-.
[5] CHEN Yan-hong, CUI Hong-guang. High density porous polyethylene material (Medpor) as an unwrapped orbital implant[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2006, 7(8 ): 14-.
[6] ZHU Zhi-wei, YANG Ru-Lai, DONG Gui-juan, ZHAO Zheng-yan. Study on the neurotoxic effects of low-level lead exposure in rats[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2005, 6( 7): 15-.