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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2016, Vol. 17 Issue (5): 333-341    DOI: 10.1631/jzus.B1500247
Reviews     
Multifunctional protein: cardiac ankyrin repeat protein
Na Zhang, Xiao-jie Xie, Jian-an Wang
Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
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Abstract  Cardiac ankyrin repeat protein (CARP) not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now. In this review, we will discuss the continued progress in the research related to CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases.

Key words： Cardiac ankyrin repeat protein (CARP)      Cardiovascular disease      Cardiac development     
Received: 12 October 2015      Published: 04 May 2016
CLC:  R34  
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Na Zhang, Xiao-jie Xie, Jian-an Wang. Multifunctional protein: cardiac ankyrin repeat protein. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(5): 333-341.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1500247     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2016/V17/I5/333

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