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| Microcalorimetry studies of the antimicrobial actions of Aconitum alkaloids |
| Yan-bin Shi, Lian Liu, Wei Shao, Ting Wei, Gui-mei Lin |
| 1School of Mechanical and Automotive Engineering, Qilu University of Technology, Jinan 250353, China; 2Beijing Health Vocational College, Beijing 100053, China; 3School of Pharmaceutical Science, Shandong University, Jinan 250012, China |
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Abstract The metabolic activity of organisms can be measured by recording the heat output using microcalorimetry. In this paper, the total alkaloids in the traditional Chinese medicine Radix Aconiti Lateralis were extracted and applied to Escherichia coli and Staphylococcus aureus. The effect of alkaloids on bacteria growth was studied by microcalorimetry. The power-time curves were plotted with a thermal activity monitor (TAM) air isothermal microcalorimeter and parameters such as growth rate constant (μ), peak-time (Tm), inhibitory ratio (I), and enhancement ratio (E) were calculated. The relationships between the concentration of Aconitum alkaloids and μ of E. coli or S. aureus were discussed. The results showed that Aconitum alkaloids had little effect on E. coli and had a potentially inhibitory effect on the growth of S. aureus.
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Received: 18 May 2015
Published: 04 August 2015
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