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| Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia |
| Jing Zhao, Hui-min Yan, Ya Li, Jia Wang, Lu Han, Zhi-hao Wang, Meng-xiong Tang, Wei Zhang, Yun Zhang, Ming Zhong |
| Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Ji’nan 250012, China; Department of Cardiology, Qilu Hospital of Shandong University, Ji’nan 250012, China; Department of Cardiology, Longfu Hospital of Dongcheng District, Beijing 100010, China; Department of Geriatrics, Qilu Hospital of Shandong University, Ji’nan 250012, China; Department of Emergency, Qilu Hospital of Shandong University, Ji’nan 250012, China |
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Abstract Background: Statins have proven efficacy in inhibiting the onset and progress of atherosclerosis. The effectiveness of pitavastatin in reversing carotid atherosclerosis associated with hypercholesterolemia (HC) is unknown. Objectives: To explore the simultaneous effects of pitavastatin calcium on brachial arterial flow-mediated vasodilatation (FMD), carotid intima-media thickness (IMT), and arterial stiffness (β), three surrogate markers of atherosclerosis were studied in HC patients. Methods: A randomized, double-blind trial was performed with 40 HC subjects who fulfilled the inclusion/exclusion criteria. Patients were given pitavastatin calcium 1 mg/d (Group 1) or 2 mg/d (Group 2) for 8 weeks. There were 20 patients in each group, and 30 gender- and age-matched healthy subjects as controls were recruited. FMD of the brachial artery, carotid IMT, and arterial stiffness indicated by β were measured at baseline and at 8 weeks after starting pitavastatin calcium therapy using ultrasound techniques. Biochemical tests were also made on all subjects. Results: At baseline, higher total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), reduced FMD, and increased β and IMT were observed in HC patients (P<0.001 for all) compared with controls. After 8 weeks, TC was decreased by 20.59%/27.56% and LDL-C 30.92%/35.64%, respectively, in comparison to baseline groups; the HC groups had reduced β and improved endothelial function over the 8-week follow-up (P<0.05–0.001); nonetheless, no significant alterations of IMT were found (P>0.05). Significant negative interactions between TC/LDL and FMD (P<0.05–0.001), positive interactions between TC and IMT (P=0.003) and between TC/LDL and β (P<0.001–0.000) were found. Conclusions: Treatment with pitavastatin calcium exerted favorable effects on endothelial function and arterial stiffness. It also improved carotid atherosclerosis in patients with HC.
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Received: 30 June 2014
Published: 04 May 2015
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Cite this article:
Jing Zhao, Hui-min Yan, Ya Li, Jia Wang, Lu Han, Zhi-hao Wang, Meng-xiong Tang, Wei Zhang, Yun Zhang, Ming Zhong. Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(5): 380-387.
URL:
http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1400181 OR http://www.zjujournals.com/xueshu/zjus-b/Y2015/V16/I5/380
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