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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2011, Vol. 12 Issue (3): 189-192    DOI: 10.1631/jzus.B1000265
Biomedicine     
Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning
Yuan-qiang Lu, Jiu-kun Jiang, Wei-dong Huang
Department of Emergency, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
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Abstract  Objective: To report clinical features and treatment of 16 cases of acute 2,4-dinitrophenol poisoning. Methods: A total of 16 patients suffering from acute poisoning due to non-oral exposure to 2,4-dinitrophenol were sent to our hospital. Two died within 3 h after admission, while the other 14 responded to supportive treatment and hemoperfusion. Clinical features and treatment of the patients were retrospectively analyzed and presented. Results: Fourteen patients recovered and were discharged after four to six weeks of treatment. No obvious poisoning sequelae were found in the three-month follow-up. Conclusions: Non-oral exposure to 2,4-dinitrophenol is toxic. Hemoperfusion and glucocorticoid treatments may be efficient measures to prevent mortality, but this requires further study.

Key words： 4-Dinitrophenol      Poisoning      Therapeutics      Hemoperfusion      Glucocorticoid     
Received: 08 July 2010      Published: 09 March 2011
CLC:  R135.1  
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Yuan-qiang Lu
Jiu-kun Jiang
Wei-dong Huang
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Yuan-qiang Lu, Jiu-kun Jiang, Wei-dong Huang. Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2011, 12(3): 189-192.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1000265     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2011/V12/I3/189

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