| Biotechnology |
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| L-Proline as an efficient and reusable promoter for the synthesis of coumarins in ionic liquid |
| Xiu-hong LIU, Ji-cai FAN, Yang LIU, Zhi-cai SHANG |
| Department of Chemistry, Zhejiang University, Hangzhou 310027, China |
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Abstract The effect of L-proline as a promoter on the condensation reaction of salicylaldehyde or its derivatives with ethyl acetoacetate in neutral ionic liquid [emim]BF4 was studied. All reactions were carried out under mild reaction conditions and achieved high yields. Moreover, the ionic liquid containing L-proline could be recycled and reused for several times without noticeably decreasing in productivity. The results show that the L-proline-[emim]BF4 system has a potential in contribution to the development of environmentally friendly and inexpensive processes in organic syntheses.
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Received: 13 March 2008
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