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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2007, Vol. 8 Issue (7): 526-532    DOI: 10.1631/jzus.2007.B0526
Pharmaceutical Sciences     
Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines
MALLIKARJUNA B.P., SURESH KUMAR G.V., SASTRY B.S., NAGARAJ, MANOHARA K.P.
Department of Medicinal Chemistry, St. Johns Pharmacy College, Bangalore-560040, Karnataka, India; Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530002, Andhra Pradesh, India; Pharmacy Department, M.S. University, Baroda-390002, Gujarat, India; Department of Pharmacognosy, Dr. H.L.T. College of Pharmacy, Bangalore-571502, Karnataka, India
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Abstract  In the present research, a series of 5,6-bis aryl 1,2,4-triazines 5a~5f were synthesized by condensation of various benzils 4a~4f with aminoguanidine bicarbonate and were screened in vivo, for their anticonvulsant and neurotoxicity studies. Compounds 5a, 5b and 5d were found to be potent molecules of this series, when compared with the reference drugs phenytoin sodium, diazepam and lamotrigine. The structures of these compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopic data.

Key words： 5,6-Bis aryl 1,2,4-triazines      Synthesis      Anticonvulsant activity     
Received: 05 February 2007     
CLC:  R914.5  
  TQ460.7+2  
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MALLIKARJUNA B.P.
SURESH KUMAR G.V.
SASTRY B.S.
NAGARAJ
MANOHARA K.P.
Cite this article:

MALLIKARJUNA B.P., SURESH KUMAR G.V., SASTRY B.S., NAGARAJ, MANOHARA K.P.. Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2007, 8(7): 526-532.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2007.B0526     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2007/V8/I7/526

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