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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2006, Vol. 7 Issue (9 ): 16-    DOI: 10.1631/jzus.2006.B0766
    
Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation?
LI Nan, WANG Jian-an
Division of Clinical Pharmacology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; Division of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
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Abstract  We observed in a pilot study that there was a transient elevation of brain natriuretic peptide (BNP) level shortly after the transplantation in the patient with ischemic heart failure, which is unexplainable by the simultaneous increase of the cardiac output and six-minute walk distance. Similar findings were observed in the phase I trial. We postulated on the basis of the finding of Fukuda in vitro that this transient elevation of BNP level against the improvement of cardiac function and exercise capacity might indicate cardiomyogenesis in patients after mesenchymal stem cell transplantation. Further study is warranted to verify the hypothesis.

Key words： Mesenchymal stem cell transplantation      Brain natriuretic peptide      Cardiac function      Exercise capacity      Cardiomyogenesis     
Received: 13 March 2006     
CLC:  R54  
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Cite this article:

LI Nan, WANG Jian-an. Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation?. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2006, 7(9 ): 16-.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2006.B0766     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2006/V7/I9 /16

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