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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2005, Vol. 6 Issue (10): 1-    DOI: 10.1631/jzus.2005.B0941
    
Acute phase reactants, challenge in the near future of animal production and veterinary medicine
GRUYS E., TOUSSAINT M.J.M., UPRAGARIN N., VAN EDEREN A.M., ADEWUYI A.A., CANDIANI D., NGUYEN T.K.A., SABECKIENE (BALCIUTE) J.
Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands; Department of Farm Resources and Production Medicine, Faculty of Veterinary Medicine, Kasetsart University, Nakhon Pathom, Thailand; Department of Veterinary Morphophysiology, University of Torino, Italy; Department of Embryo Transfer and Reproduction, the National Institute of Animal Husbandry, Hanoi, Vietnam; Department of Infectious Diseases, Lithuanian Veterinary Academy, Kaunas, Lithuania
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Abstract  The future of acute phase proteins (APPs) in science is discussed in this paper. Many functions and associated pathological processes of APPs are unknown. Extrahepatic formation in local tissues needs attention. Local serum amyloid A (SAA) formation may be involved in deposition of AA-amyloid induced by conformational change of SAA resulting in amyloid formation, having tremendous food safety implications. Amyloidogenesis is enhanced in mouse fed beta pleated sheet-rich proteins. The local amyloid in joints of chicken and mammary corpora amylacea is discussed. Differences in glycosylation of glycoproteins among the APPs, as has been shown for α1-acid glycoprotein, have to be considered. More knowledge on the reactivity patterns may lead to implication of APPs in the diagnostics and staging of a disease. Calculation of an index from values of several acute phase variables increases the power of APPs in monitoring unhealthy individuals in animal populations. Vaccinations, just as infections in eliciting acute phase response seem to limit the profitability of vaccines because acute phase reactions are contraproductive in view of muscle anabolism. Interest is focused on amino acid patterns and vitamins in view of dietary nutrition effect on sick and convalescing animals. When inexpensive methodology such as liquid phase methods (nephelometry, turbidimetry) or protein array technology for rapid APP measurement is available, APPs have a future in routine diagnostics. Specific groups of patients may be screened or populations monitored by using APP.

Key words： Acute phase protein      Amino acid      Joint      Mammary gland      Mastitis      Serum amyloid A (SAA)      Vitamin A     
Received: 25 July 2005     
CLC:  Q95  
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GRUYS E.
TOUSSAINT M.J.M.
UPRAGARIN N.
VAN EDEREN A.M.
ADEWUYI A.A.
CANDIANI D.
NGUYEN T.K.A.
SABECKIENE (BALCIUTE) J.
Cite this article:

GRUYS E., TOUSSAINT M.J.M., UPRAGARIN N., VAN EDEREN A.M., ADEWUYI A.A., CANDIANI D., NGUYEN T.K.A., SABECKIENE (BALCIUTE) J.. Acute phase reactants, challenge in the near future of animal production and veterinary medicine. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2005, 6(10): 1-.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2005.B0941     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2005/V6/I10/1

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