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ZJUS-A
Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering)  2001, Vol. 2 Issue (1): 107-110    DOI: 10.1631/jzus.2001.0107
Medicine     
EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES
WANG Da, HE Chao, DING Wei, WANG Hui-ping
First Affiliated Hospital,Medical College,Zhejiang University,Hangzhou 310003,China; Sir Run Run Shaw Hospital,Medical College,Zhejiang University,Hangzhou 310016,China
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Abstract  To study the function of transforming growth factor β1 (TGF-β1) and transforming growth factor-β type II receptor (TGF-βR II) in varying stages of colorectal adenoma during neoplastic transformation, fifty-five cases of resected colorectal adenomas were examined immunohistochemically. Our results showed that the expression of TGF-β1 ranged from high to low, with the progression of low-grade to high-grade dysplasia of adenomas to carcinoma. And there was significantly different expression of TGF-β1 between moderate and high dysplasia adenomas (P<0.05), but no significantly different expression of TGF-β R II was found among varying stages of adenomas. Our results suggested that the quantities of TGF-β1 secreted by adenoma cells decrease dramatically in moderate to severe dysplasia colorectal adenomas. It is the decreased secretion of TGF-β1, rather than the mutated TGF-βR II that may play an important role in transforming colorectal adenomas to adenocarcinomas.

Key words： colorectal adenomas,TGF-β1,TGF-βR II,immunohistochemistry     
Received: 18 June 2000     
CLC:  R574  
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HE Chao
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WANG Da, HE Chao, DING Wei, WANG Hui-ping. EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 2001, 2(1): 107-110.

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http://www.zjujournals.com/xueshu/zjus-a/10.1631/jzus.2001.0107     OR     http://www.zjujournals.com/xueshu/zjus-a/Y2001/V2/I1/107

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