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| Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction |
| LUO Ben-yan, CHEN Zhi, CHEN Feng, LI Xia, PAN Xiao-ping |
| Department of Neurology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China; Institute of Infectious Diseases, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China |
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Abstract Objective: To explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI). Methods: Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls. Results: The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group (P=0.011). Conclusions: 465C/G,462C/G and 451delC polymorphisms might be associated with ACI.486GT allele might have protective effect on the pathogenesis of ACI.
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Received: 18 April 2003
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