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Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering)  2003, Vol. 4 Issue (2): 214-220    DOI: 10.1631/jzus.2003.0214
Applied Physics & Mathematics     
Adaptive designs for sequential experiments
LIN Zheng-yan, ZHANG Li-xin
Department of Mathematics, Zhejiang University, Hangzhou 310028, China
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Abstract  Various adaptive designs have been proposed and applied to clinical trials, bioassay, psychophysics, etc.Adaptive designs are also useful in high cost engineering trials.More and more people have been paying attention to these design methods. This paper introduces several broad families of designs, such as the play-the-winner rule, randomized play-the-winner rule and its generalization to the multi-arm case, doubly biased coin adaptive design, Markov chain model.

Key wordsClinical trial      Adaptive designs      (Randomized) Play-the-winner rule      Biased coin design      Markov chain      Asymptotic properties      Urn model     
Received: 06 May 2002     
CLC:  O211.4  
Cite this article:

LIN Zheng-yan, ZHANG Li-xin. Adaptive designs for sequential experiments. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 2003, 4(2): 214-220.

URL:

http://www.zjujournals.com/xueshu/zjus-a/10.1631/jzus.2003.0214     OR     http://www.zjujournals.com/xueshu/zjus-a/Y2003/V4/I2/214

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