| Biomedical Science |
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| MRS study on lentiform nucleus in idiopathic Parkinson\'s disease with unilateral symptoms |
| ZHENG Xu-ning, ZHU Xiong-chao, RUAN Ling-xiang, ZHANG Ling-ju, Yuan Min, SHANG De-sheng, LIU Yang |
| The first affiliated hospital, College of medicine, Zhejiang University, Hangzhou 310003, China; Department of Neurology, University of Goettingen, Germany |
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Abstract Objective: To investigate changes in magnetic resonance spectroscopy (MRS) of lentiform nucleus during the early stage of Parkinson\'s disease. Methods: Twenty-five patients with idiopathic Parkinson disease with unilateral symptoms (IPDUS) and 25 healthy volunteers were enrolled in this study. MRS of the lentiform nucleus in each patient was taken and then concentrations of N-acetylaspartate (NAA), Creatine (Cr) and Choline (Cho) were calculated. Results: Compared to that in the control, NAA/(Cho+Cr) was significantly lower in the lentiform nucleus contralateral to symptoms and even that in the ipsilateral side in IPDUS patients (all P<0.05); while there was no difference between the two sides in the healthy volunteer (P>0.05). The ratio of NAA/(Cho+Cr) ipsilateral to the sympatomatic side of the patient was also lower than that of the control (P<0.05). Conclusions: there might be some changes with MRS on the lentiform nucleus during the early stage of idiopathic Parkinson\'s disease with unilateral symptom. MRS may be one of the reliable methods for early or even sub-clinical diagnosis.
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Received: 01 November 2002
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