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| A new germacranolide from Carpesium cernuum |
| CAO Jian-xin, PAN Yuan-jiang, XU Chong-yang, HUANG Li-xia, MA Shu-hong, DAI Chang-liang, GAO Wan-wan |
| Department of Chemistry, Zhejiang University, Hangzhou 310027, China; Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China |
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Abstract As a part of our interest in biologically active germacranolides from the genus Carpesium (Compositae), we have investigated the constituents of Carpesium cernuum. This paper reports the isolation and structural elucidation of a new germacranolide, cernolide A (Compound 1), from the herb. The structure of Compound 1 was determined as 2a,3b-dihydroxy-9-angeloxygermacra-4-en-6,12-olide on the basis of spectral evidence. The skeleton of Compound 1 was elucidation by IR, MS, 1H and 13C NMR, COSY, HMQC and HMBC experiments. The stereochemistry of Compound 1 was deduced by ROESY spectral data. Finally, the procedures of extraction and isolation were described in detail.
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Received: 01 March 2005
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