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ZJUS-A
Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering)  2004, Vol. 5 Issue (2): 222-225    DOI: 10.1631/jzus.2004.0222
Biomedical Science     
Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays
SHEN Qian-yun, ZHENG Shu-sen
Department of Surgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
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Abstract  In order to study the molecular mechanism of the inhibitory effect of 1,25-dihydroxyvitamin D3 on dendritic cells, experiments were performed using Atlas cDNA expression arrays from Clonetech to identify the differentially expressed genes of dendritic cells by 1,25-dihydroxyvitamin D3. Analysis of cDNA arrays revealed changes in the expression of 9 genes, including those involved in DNA binding and transcription, extracellular cell signaling and communication, intracellular transducers, as well as cell adhesions. The results indicated that a multiple molecular network is involved in the inhibitory role of 1,25-dihydroxyvitamin D3 on dendritic cells. The Atlas Array technology may facilitate the elucidation of complex pharmacological process of 1,25-dihydroxyvitamin D3 on dendritic cells.

Key words： 1,25-dihydroxyvitamin D3      Dendritic cells      Gene expression      cDNA array     
Received: 27 February 2003     
CLC:  TP391.72  
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SHEN Qian-yun
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SHEN Qian-yun, ZHENG Shu-sen. Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 2004, 5(2): 222-225.

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http://www.zjujournals.com/xueshu/zjus-a/10.1631/jzus.2004.0222     OR     http://www.zjujournals.com/xueshu/zjus-a/Y2004/V5/I2/222

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