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ZJUS-A
Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering)  2002, Vol. 3 Issue (4): 475-479    DOI: 10.1631/jzus.2002.0475
Biotechnology & Life Sciences     
Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca2+ transport
SHEN Sheng-rong, YU Hai-ning, JIN Chao-fang
Department of Tea Sciences, Zhejiang University, Hangzhou 310029, China
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Abstract  The authors investigated the influence of green tea polyphenols (GTPs) on the liver mitochondria permeability transition pore (PTP) opening through mit ochondria swelling and change of mitochondria membrane potential. The data showed that GTPs had obvious protective effect on the Ca2+-induced PTP opening in a dose-dependent manner detected by mitochondria swelling. The results were obtained by measuring the change of mitochondria membrane potential through Rh 123. Further experiments were conducted to examine the detailed influence of GTPs on Ca2+ import and export of mitochondria. The results showed that GTPs had remarkably inhibitory effect on the Ca2+-induced Ca2+ import in mitochondria; and that they could accelerate Ca2+-release from mitochondria. Our data provide an alternate interpretation of the potent protective function of GTPs on cell against apoptosis.

Key words： Mitochondria      PTP green tea polyphenols      mCICR      Ca2+ transport      Mitochondria ΔΨm     
Received: 06 May 2001     
CLC:  Q244  
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YU Hai-ning
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JIN Chao-fang
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SHEN Sheng-rong, YU Hai-ning, JIN Chao-fang. Influence of green tea polyphenols on mitochondrial permeability transition pore and Ca2+ transport. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 2002, 3(4): 475-479.

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http://www.zjujournals.com/xueshu/zjus-a/10.1631/jzus.2002.0475     OR     http://www.zjujournals.com/xueshu/zjus-a/Y2002/V3/I4/475

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