Abstract：An adsorption stripping voltammetry for determination of praziquantel (PQT) was reported. In pH=10. Na}B,O,-NaOH medium,PQT produces a very sensitive adsorption reduction peak on HMDE.Thethepeak potential is一1. 29V(vs. SCE). The peak current is linear with the concentration of PQT inrange of 2. 0 X 10一7一8. 0 X 10-fimol·L一’.The detection limit isconditions for the determination of PQT have been discussed in detail.2. 0 X 10-smol·L一’.The optimalThe behaviour of electrochemicalon HMDE was explored. The method has been applied to determination of PQT in medicinal tablet. Theresult is satisfactory.