Abstract:The enthalpies of dilution of l-serine in water/DMF mixtures(in 10% increments ranging from 5% to 45% DMF by mass) were measured with LKB 2277 Bio Activity Monitor at 298. 15 K.Calculations show that the relative partial molar enthapies of l-serine in the studied solutions vary linearly with molality. The value of pairwise enthalpic interaction coefficients is negative and decreases with increasing the DMF concentration in the mixed solvents.