摘要本文应用放免法测定了 40例败血症休克新生儿血浆 ET 水平.结果表明: ( 1)新生儿败血症休克组 血浆 ET 水平明显高于对照组,重度休克高于轻中度休克, 死亡组高于存活组, 对休克存活组 18 例血浆 ET 水平进行动态观察,发现随着休克的纠正及病情好转, 血浆 ET 也逐渐恢复正常.( 2) G -菌感染儿血 浆 ET 高于 G+菌感染儿.( 3)休克时 ET 与 BUN 、血 Cr 呈正相关, 与 PO2、BE 呈负相关,提示 ET 参与新 生儿败血症休克的病理生理过程,并与疾病的严重程度及预后有关.
Abstract：The concentration of plasma endothelin( ET)is measured by radioimmunoassay in 40 newborn babies with septic shock. The results show that:①the valuesof ET are markedly increased in shock patients comparedw ith those in control, those in bad shock with in mild, those in bad group with those still alive. By researchiny ET of 18 patients still alive,It is found that ET becomes normal step by step as shock disappears.②ET in G -infection patients is higher than that in G+ infection patients.③In shock patients, ET is in proportion either pasitively to BUN ,Cr or negtively to PO2,BE. It indicates that ET may be involved in pathophysiological processes of newborn septic shock and is correlated with severness of disease and prognosis.