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J Zhejiang Univ (Med Sci)  2020, Vol. 49 Issue (2): 203-208    DOI: 10.3785/j.issn.1008-9292.2020.03.02
    
Clinical analysis of suspected COVID-19 patients with anxiety and depression
LI Xin1(),DAI Tian2,WANG Hong1,*(),SHI Junnian1,YUAN Wei1,LI Jing1,CHEN Lijun1,ZHANG Tianming1,ZHANG Shanshan1,KONG Yan1,YUE Ning1,SHI Hui1,HE Yuping1,HU Huifang1,LIU Furong1,YANG Caixia1
1. Fever Isolation Ward, Lanzhou University Second Hospital, Lanzhou 730030, China
2. School of Public Health, Lanzhou University, Lanzhou 730000, China
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Abstract  

Objective: To explore the risk factors of anxiety and depression in patients with suspected coronavirus disease 2019 (COVID-19) so as to achieve early intervention and better clinical prognosis. Methods: Seventy-six patients with suspected COVID-19 in fever isolation wards of Second Hospital of Lanzhou University were enrolled From January 31, 2020 to February 22, 2020. Their clinical baseline data were collected. The anxiety of patients was assessed by Hamilton Anxiety Scale, and the depression of patients was assessed by Hamilton Depression Scale. Multivariate Logistic regression analysis was performed to explore the risk factors of anxiety and depression in these patients. Results: Female patients are more likely to have anxiety (OR=3.206, 95%CI:1.073-9.583, P < 0.05) and depression (OR=9.111, 95%CI:2.143-38.729, P < 0.01) than male patients; patients with known contact history of epidemic area and personnel in epidemic area are more likely to have depression (OR=3.267, 95%CI:1.082-9.597, P < 0.05). Conclusion: During the isolation treatment of suspected COVID-19 patients, early psychological intervention should be carried out for the female patients with known contact history of epidemic area and personnel in epidemic area, and drug treatment should be given in advance if necessary.



Key wordsCoronavirus disease 2019      Severe acute respiratory syndrome coronavirus 2      Novel coronavirus pneumonia      Anxiety      Depression      Logistic models     
Received: 27 February 2020      Published: 06 March 2020
CLC:  R749.2  
Corresponding Authors: WANG Hong     E-mail: xin830910@163.com;1311098171@qq.com
Cite this article:

LI Xin,DAI Tian,WANG Hong,SHI Junnian,YUAN Wei,LI Jing,CHEN Lijun,ZHANG Tianming,ZHANG Shanshan,KONG Yan,YUE Ning,SHI Hui,HE Yuping,HU Huifang,LIU Furong,YANG Caixia. Clinical analysis of suspected COVID-19 patients with anxiety and depression. J Zhejiang Univ (Med Sci), 2020, 49(2): 203-208.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2020.03.02     OR     http://www.zjujournals.com/med/Y2020/V49/I2/203


2019冠状病毒病(COVID-19)疑似患者合并焦虑和抑郁的临床分析

目的: 分析2019冠状病毒病(COVID-19)疑似患者伴发焦虑、抑郁的危险因素以便早期干预以改善临床预后。方法: 收集2020年1月31日至2月22日兰州大学第二医院发热隔离病房收治的COVID-19疑似患者76例,收集其临床资料并采用汉密尔顿焦虑量表评测患者焦虑情况,汉密尔顿抑郁量表评测患者抑郁情况,行多因素Logistic回归分析COVID-19疑似患者出现焦虑或抑郁的危险因素。结果: 女性患者较男性患者更易伴发焦虑(OR=3.206,95%CI:1.073~9.583,P < 0.05)和抑郁情绪(OR=9.111,95%CI:2.143~38.729,P < 0.01);患者存在已知疫区及疫区人员接触史更容易伴发抑郁情绪(OR=3.267,95%CI:1.082~9.597,P < 0.05)。结论: 在COVID-19疑似患者隔离治疗期间,对于存在已知疫区及疫区人员接触史的女性患者应该早期进行心理干预,必要时提早给予药物治疗,以改善患者预后。


关键词: 2019冠状病毒病,  严重急性呼吸综合征冠状病毒2,  新型冠状病毒肺炎,  焦虑,  抑郁,  Logistic模型 
组 别 n 女 性 年龄(岁) 受教育程度
(本科及以上)
已 婚 已知疫区及疫区
人员接触史
已知外出旅行史或
聚众性场所活动史
既往确诊
精神疾病史
  “—”无相关数据.COVID-19:2019冠状病毒病.
伴发焦虑组 36 21(58.3) 38±18 16(44.4) 36(100.0) 8(22.2) 12(33.3) 4(11.1)
不伴发焦虑组 40 14(35.0) 34±12 21(52.5) 36(90.0) 7(17.5) 6(15.0) 4(10.0)
t/χ2 4.152 -0.959 0.492 2.059 0.267 3.523 0.000
P <0.05 >0.05 >0.05 >0.05 >0.05 >0.05 >0.05
Tab 1 General characteristics of suspected COVID-19 patients with and without anxiety   [n(%)或\begin{document}$\bar x \pm s$\end{document}]
组 别 n 女 性 年龄(岁) 受教育程度
(本科及以上)
已 婚 已知疫区及疫区
人员接触史
已知外出旅行史或
聚众性场所活动史
既往确诊
精神疾病史
  “—”无相关数据.COVID-19:2019冠状病毒病.
伴发抑郁组 23 19(82.6) 38±16 10(43.5) 19(82.6) 10(43.5) 6(26.1) 3(13.0)
不伴发抑郁组 53 16(30.2) 35±15 37(69.8) 53(100.0) 5(9.4) 12(22.6) 5(9.4)
t/χ2 17.740 -0.874 0.358 6.554 9.684 0.105 0.004
P <0.01 >0.05 >0.05 <0.05 <0.01 >0.05 >0.05
Tab 2 General characteristics of suspected COVID-19 patients with and without depression  [n(%)或\begin{document}$\bar x \pm s$\end{document}]
变 量 β S.E. Wald P OR(95%CI)
  因婚姻状况中未婚者所占比例过小,且婚姻状况与年龄存在一定的共线性,遂未将婚姻状况纳入多因素Logistic回归分析.COVID-19:2019冠状病毒病.
女性 1.165 0.559 4.350 <0.05 3.206(1.073~9.583)
年龄 -0.005 0.020 0.055 >0.05 0.995(0.957~1.035)
受教育程度(本科及以上) -0.588 0.534 1.213 >0.05 0.556(0.195~1.581)
已知疫区及疫区人员接触史 0.315 0.810 0.151 >0.05 1.370(0.280~6.706)
已知外出旅行史或聚众性场所活动史 1.040 0.625 2.771 >0.05 2.829(0.832~9.623)
既往确诊精神疾病史 -0.778 0.922 0.712 >0.05 0.459(0.075~2.799)
Tab 3 Multivariate logistic regression analysis of anxiety in patients with suspected COVID-19
变 量 β S.E. Wald P OR(95%CI)
  因婚姻状况中未婚者所占比例过小,且婚姻状况与年龄存在一定的共线性,遂未将婚姻状况纳入多因素Logistic回归分析.COVID-19:2019冠状病毒病.
女性 2.209 0.738 8.955 <0.01 9.111(2.143~38.729)
年龄 0.004 0.025 0.022 >0.05 1.004(0.956~1.054)
受教育程度(本科及以上) 0.233 0.721 0.104 >0.05 1.262(0.307~5.188)
已知疫区及疫区人员接触史 1.156 0.539 4.340 <0.05 3.267(1.082~9.597)
已知外出旅行史或聚众性场所活动史 0.739 0.764 0.934 >0.05 2.093(0.468~9.361)
既往确诊精神疾病史 -0.363 0.994 0.133 >0.05 0.695(0.099~4.883)
Tab 4 Multivariate logistic regression analysis of depression in patients with suspected COVID-19
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