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Journal of ZheJiang University(Medical Science)  2016, Vol. 45 Issue (3): 308-314    DOI: 10.3785/j.issn.1008-9292.2019.05.15
    
Zinc and autophagy
LIU Qiaoyun1, SHEN Hanming2, XIA Dajing1
1. Department of Toxicology, School of Public Health, Zhejiang University, Hangzhou 310058, China;
2. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore
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Abstract  

Autophagy refers to a catabolic process,in which the damaged organelles or biological macromolecules, such as protein aggregates, are degraded via lysosome. The completion of autophagy depends on a series of autophagy-related genes (Atgs) and many upstream regulatory molecules. Zinc is an essential trace element, and plays an important role in the process of autophagy as a component of enzymes and structural proteins like zinc transporters or zinc finger protein. The regulation of autophagy is closely associated with the zinc ion homeostasis. In addition, many studies suggest that the protective effects of zinc on cells are likely to be done by autophagy. This review aims to summarize the current research progress and discuss the reciprocal regulation mechanism between zinc and autophagy, which may provide insights into the intricate roles of autophagy in diseases and find novel strategies for treatment and prevention of human diseases.



Key wordsZinc      Autophagy      Neoplasms      Review     
Received: 19 October 2015     
CLC:  R225  
Cite this article:

LIU Qiaoyun, SHEN Hanming, XIA Dajing. Zinc and autophagy. Journal of ZheJiang University(Medical Science), 2016, 45(3): 308-314.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2019.05.15     OR     http://www.zjujournals.com/xueshu/med/Y2016/V45/I3/308


锌与自噬

细胞自噬主要指对胞质内受损的细胞器或生物大分子进行降解和回收利用的过程。自噬过程依赖于溶酶体,并由一系列复杂的信号分子进行调控。锌元素通过锌转运蛋白和锌指蛋白等多种酶或蛋白发挥催化和结构作用,在自噬的发生发展过程中发挥了重要作用。自噬调节紊乱同样也会导致胞内锌离子代谢稳态的重大改变。许多研究结果还提示锌对细胞的保护作用很可能是通过自噬来实现的。本文总结了当前国内外自噬研究进展,重点介绍锌在细胞自噬过程中发挥的作用和细胞自噬在锌代谢中的作用以及自噬介导的锌对细胞的保护作用等,揭示锌与自噬之间相互调控的发生机制,阐明自噬与疾病之间的关系,以期为治疗和预防多种人类重大疾病提供相关思路。


关键词: 锌,  自噬,  肿瘤,  综述 
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