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J Zhejiang Univ (Med Sci)  2019, Vol. 48 Issue (2): 219-223    DOI: 10.3785/j.issn.1008-9292.2019.04.15
    
Effects of aerobic glycolysis on pathogenesis and drug resistance of non-Hodgkin lymphoma
XU Li1(),XU Ming2,TONG Xiangmin3,*()
1. Department of Oncology, the First People's Hospital of Tongxiang, Tongxiang 314500, Zhejiang Province, China
2. Department of Traditional Chinese Medicine, the First People's Hospital of Tongxiang, Tongxiang 314500, Zhejiang Province, China
3. Department of Hematology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China
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Abstract  

It has been shown that aerobic glycolysis (AG) plays an important role in the pathogenesis and resistance mechanism of non-Hodgkin lymphoma (NHL) in recent years. Signaling pathway related to abnormal activation of AG can increase the level of AG in lymphatic and hematopoietic cells, while the enzymes related to the activity of AG are involved in the pathogenesis and prognosis of NHL. Drugs that inhibit AG can also inhibit NHL cells in vitro. Drugs inhibiting AG may increase the sensitivity of chemotherapeutic agents and prevent drug resistance. In this article, the role of signaling pathway proteins and regulatory genes related to AG in the pathogenesis and drug resistance of NHL are reviewed, and the AG as a target in the clinical diagnosis and treatment of NHL is discussed.



Key wordsLymphoma, non-hodgkin/etiology      Drug tolerance      Glycolysis      Oxygen      Review     
Received: 16 December 2018      Published: 24 July 2019
CLC:  R364  
  R552  
Corresponding Authors: TONG Xiangmin     E-mail: Laraky@sina.com;xiangmintong@126.com
Cite this article:

XU Li,XU Ming,TONG Xiangmin. Effects of aerobic glycolysis on pathogenesis and drug resistance of non-Hodgkin lymphoma. J Zhejiang Univ (Med Sci), 2019, 48(2): 219-223.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2019.04.15     OR     http://www.zjujournals.com/med/Y2019/V48/I2/219


有氧糖酵解在非霍奇金淋巴瘤发病及耐药机制中的作用

近年来肿瘤代谢研究日益得到重视,大量研究显示有氧糖酵解在非霍奇金淋巴瘤发病及耐药机制中扮演了重要角色。有氧糖酵解相关信号通路的异常激活可增加淋巴造血细胞的有氧糖酵解水平,而有氧糖酵解相关酶的活性与非霍奇金淋巴瘤(NHL)的发病和预后相关。抑制有氧糖酵解的药物对体外培养的NHL细胞具有杀伤作用,联合常规化疗药物可增加化疗药物的敏感性和预防耐药。本文综述了有氧糖酵解相关信号通路蛋白和调控基因在NHL发病以及耐药中的作用,揭示了有氧糖酵解的深入研究在NHL临床诊断和治疗中的价值。


关键词: 淋巴瘤, 非霍奇金/病因学,  药物耐受性,  糖酵解,  氧,  综述 
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