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J Zhejiang Univ (Med Sci)  2019, Vol. 48 Issue (1): 116-120    DOI: 10.3785/j.issn.1008-9292.2019.02.17
Research advances on the role of exosomes in chemotherapy resistance of ovarian cancer
SHEN Xiameng(),LYU Weiguo()
Department of Gynecology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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Chemotherapy resistance is one of the biggest challenges in treatment of ovarian cancer. Mounting evidence shows that the exosomes shedding from tumor cells are considered to be involved in chemotherapy resistance of ovarian cancer by enhanced exosomal export of drugs, transferring RNAs or proteins and interfering with the bioactivity of therapeutic anti-tumor antibodies. In this review, we display the correlation between exosomes and chemotherapy resistance of ovarian cancer, the mechanism of exosomes involved in chemotherapy resistance of ovarian cancer, and discuss the potential clinical values of exosomes in chemotherapy resistance of ovarian cancer.

Key wordsOvarian neoplasms/drug therapy      Drug tolerance      Exosomes      Review     
Received: 30 September 2018      Published: 10 May 2019
CLC:  R737.31  
Corresponding Authors: LYU Weiguo     E-mail:;
Cite this article:

SHEN Xiameng,LYU Weiguo. Research advances on the role of exosomes in chemotherapy resistance of ovarian cancer. J Zhejiang Univ (Med Sci), 2019, 48(1): 116-120.

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关键词: 卵巢肿瘤/药物疗法,  药物耐受性,  外泌体,  综述 
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